Quinolone alkaloids from Evodiae fructus inhibit LFA-1/ICAM-1-mediated cell adhesion

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dc.contributor.authorSeung Woong Lee-
dc.contributor.authorJong Sun Chang-
dc.contributor.authorLim Juhwan-
dc.contributor.authorKim Minseok-
dc.contributor.authorSu-Jin Park-
dc.contributor.authorHyung Jae Jung-
dc.contributor.authorMin-Soo Kim-
dc.contributor.authorWoo Song Lee-
dc.contributor.authorMun Chual Rho-
dc.date.accessioned2017-04-19T09:17:32Z-
dc.date.available2017-04-19T09:17:32Z-
dc.date.issued2010-
dc.identifier.issn0253-2964-
dc.identifier.uri10.5012/bkcs.2010.31.01.064ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9450-
dc.description.abstractFour quinolone alkaloids were isolated by bioactivity-guided fractionation from the methanol extracts of Evodiae fructus fruits. Structures of compounds were elucidated by spectroscopic analysis (1H-, 13C-NMR and MS), as follows: 1-methyl-2-undecyl-4(1H)-quinolone (1), evocarpine (2), dihydroevocarpine (3) and mixture of [1-methyl-2-[(Z)-10- pentadecenyl]-4(1H)- quinolone and 1-methyl-2-[(Z)-6-pentadecenyl]-4(1H)-quinolone] (4). They inhibited the interaction of sICAM-1 and LFA-1 in THP-1 cells at IC50 values of >150 (1), 109.8 (2), >150 (3) and 40.9 μM (4), respectively.-
dc.publisherWiley-
dc.titleQuinolone alkaloids from Evodiae fructus inhibit LFA-1/ICAM-1-mediated cell adhesion-
dc.title.alternativeQuinolone alkaloids from Evodiae fructus inhibit LFA-1/ICAM-1-mediated cell adhesion-
dc.typeArticle-
dc.citation.titleBulletin of Korean Chemical Society-
dc.citation.number1-
dc.citation.endPage68-
dc.citation.startPage64-
dc.citation.volume31-
dc.contributor.affiliatedAuthorSeung Woong Lee-
dc.contributor.affiliatedAuthorJong Sun Chang-
dc.contributor.affiliatedAuthorLim Juhwan-
dc.contributor.affiliatedAuthorKim Minseok-
dc.contributor.affiliatedAuthorSu-Jin Park-
dc.contributor.affiliatedAuthorHyung Jae Jung-
dc.contributor.affiliatedAuthorMin-Soo Kim-
dc.contributor.affiliatedAuthorWoo Song Lee-
dc.contributor.affiliatedAuthorMun Chual Rho-
dc.contributor.alternativeName이승웅-
dc.contributor.alternativeName장종선-
dc.contributor.alternativeName임주환-
dc.contributor.alternativeName김민석-
dc.contributor.alternativeName박수진-
dc.contributor.alternativeName정형재-
dc.contributor.alternativeName김민수-
dc.contributor.alternativeName이우송-
dc.contributor.alternativeName노문철-
dc.identifier.bibliographicCitationBulletin of Korean Chemical Society, vol. 31, no. 1, pp. 64-68-
dc.identifier.doi10.5012/bkcs.2010.31.01.064-
dc.subject.keywordEvodiae fructus-
dc.subject.keywordRutaceae-
dc.subject.keywordQuinolone alkaloid-
dc.subject.keywordCell adhesion molecules-
dc.subject.keywordTHP-1 cells-
dc.subject.localEvodiae fructus-
dc.subject.localevodiae fructus-
dc.subject.localrutaceae-
dc.subject.localRutaceae-
dc.subject.localQuinolone alkaloid-
dc.subject.localquinolone alkaloid-
dc.subject.localCell adhesion molecule-
dc.subject.localcell adhesion molecule-
dc.subject.localCell adhesion molecules-
dc.subject.localTHP-1 cells-
dc.description.journalClassY-
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
Jeonbuk Branch Institute > Microbial Biotechnology Research Center > 1. Journal Articles
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