Triterpenoid and lignan from the fruits of Cornus kousa inhibit the activities of PRL-3 and LDL-oxidation

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Title
Triterpenoid and lignan from the fruits of Cornus kousa inhibit the activities of PRL-3 and LDL-oxidation
Author(s)
D Y Lee; M H Lee; Tae Sook Jeong; Byoung-Mog Kwon; N I Baek; Y D Rho
Bibliographic Citation
Journal of Korean Society for Applied Biological Chemistry, vol. 53, no. 1, pp. 97-100
Publication Year
2010
Abstract
Ursolic aldehyde (1) and (+)-lariciresinol (2) were isolated from the MeOH extracted fraction of the fruits of Cornus kousa by repeated column chromatographies. The structure of the compounds were determined by spectroscopic data including nuclear magnetic resonance spectrometry, mass spectrometry and infrared spectrometry Ursolic aldehyde inhibited phosphatase of regenerating liver-3 with IC50 value of 50±0.3 μM. And (+)-lariciresinol inhibited low-density lipoprotein oxidation with an IC50 value of 11.9±0.5 μM.
Keyword
Cornus kousa(+)-lariciresinolPRL-3ursolic aldehydeLDL-oxidation
ISSN
I000-0171
Publisher
Korea Soc-Assoc-Inst
DOI
http://dx.doi.org/10.3839/jksabc.2010.016
Type
Article
Appears in Collections:
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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