Oxidative stress-enhanced SUMOylation and aggregation of ataxin-1: Implication of JNK pathway

Cited 39 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorJ Ryu-
dc.contributor.authorS Cho-
dc.contributor.authorByoung Chul Park-
dc.contributor.authorD H Lee-
dc.date.accessioned2017-04-19T09:18:16Z-
dc.date.available2017-04-19T09:18:16Z-
dc.date.issued2010-
dc.identifier.issn0006291X-
dc.identifier.uri10.1016/j.bbrc.2010.01.122ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9458-
dc.description.abstractAlthough the polyglutamine protein ataxin-1 is modified by SUMO at multiple sites, the functions of such modification or how it is regulated are still unknown. Here we report that SUMO-1 or Ubc9 over-expression stimulated the aggregation of ataxin-1 and that oxidative stress, such as hydrogen peroxide treatment, further enhanced SUMO conjugation and aggregation of ataxin-1. Accordingly, co-treatment with antioxidant N-acetyl-cysteine attenuated the effect of oxidative stress. Ataxin-1, which can activate c-Jun N-terminal kinase (JNK) pathway by itself, strongly associated with apoptosis signal-regulating kinase 1 (ASK1) while not interacting with JNK. Finally, treatment of JNK-specific inhibitor caused a reduction in the oxidant-enhanced SUMOylation and aggregation of ataxin-1. Together these results indicate that SUMO modification of ataxin-1 promotes the aggregation of ataxin-1 and that oxidative stress and JNK pathway play roles in this process.-
dc.publisherElsevier-
dc.titleOxidative stress-enhanced SUMOylation and aggregation of ataxin-1: Implication of JNK pathway-
dc.title.alternativeOxidative stress-enhanced SUMOylation and aggregation of ataxin-1: Implication of JNK pathway-
dc.typeArticle-
dc.citation.titleBiochemical and Biophysical Research Communications-
dc.citation.number2-
dc.citation.endPage285-
dc.citation.startPage280-
dc.citation.volume393-
dc.contributor.affiliatedAuthorByoung Chul Park-
dc.contributor.alternativeName류주현-
dc.contributor.alternativeName조사연-
dc.contributor.alternativeName박병철-
dc.contributor.alternativeName이도희-
dc.identifier.bibliographicCitationBiochemical and Biophysical Research Communications, vol. 393, no. 2, pp. 280-285-
dc.identifier.doi10.1016/j.bbrc.2010.01.122-
dc.subject.keywordASK1-
dc.subject.keywordAtaxin-1-
dc.subject.keywordJNK-
dc.subject.keywordOxidative stress-
dc.subject.keywordPolyglutamine diseases-
dc.subject.keywordSUMO-1-
dc.subject.localASK1-
dc.subject.localAtaxin-1-
dc.subject.localJNK-
dc.subject.localOxidative stress-
dc.subject.localPolyglutamine diseases-
dc.subject.localSUMO-1-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Disease Target Structure Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.