DC Field | Value | Language |
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dc.contributor.author | K Y Oh | - |
dc.contributor.author | J H Lee | - |
dc.contributor.author | M J Curtis-Long | - |
dc.contributor.author | J K Cho | - |
dc.contributor.author | J Y Kim | - |
dc.contributor.author | Woo Song Lee | - |
dc.contributor.author | K H Park | - |
dc.date.accessioned | 2017-04-19T09:18:16Z | - |
dc.date.available | 2017-04-19T09:18:16Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0308-8146 | - |
dc.identifier.uri | 10.1016/j.foodchem.2010.01.022 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/9461 | - |
dc.description.abstract | The seeds of Psoralea corylifolia were extracted into five different polar solvents: chloroform, 50% ethanol in water, ethanol, methanol and water. All extracts were evaluated for glycosidase inhibitory activity. The chloroform extract (CE) showed the lowest IC50 values against α-glucosidase (82.9 μg/ml) and α-mannosidase (132 μg/ml). Chromatography of CE yielded nine phenolic compounds which were identified as isovabachalcone (1), 4′-O-methylbavachalcone (2), isobavachromene (3), corylifolin (4), bavachinin (5), psoralidin (6), neobavaisoflavone (7), corylifol A (8), and bakuchiol (9). All isolated compounds, apart from compound 5, possessed α-glucosidase inhibitory activities. Among them, compounds 6-8 exhibited potent inhibition with IC50s of 13.7, 27.7 and 11.3 μM, respectively. Furthermore, compounds 2 and 6 showed α-mannosidase inhibitory activity. Mechanistic analysis of their inhibition modes against α-glucosidase showed that compounds (6 and 7) were noncompetitive, whereas compound 8 was mixed. Furthermore, the most active glycosidase inhibitors (2, 6-8) were proven to be present in the native seed in high quantities by an HPLC chromatogram. | - |
dc.publisher | Elsevier | - |
dc.title | Glycosidase inhibitory phenolic compounds from the seed of Psoralea corylifolia = 보골지 씨앗으로부터 당가수분해효소 저해제 개발 | - |
dc.title.alternative | Glycosidase inhibitory phenolic compounds from the seed of Psoralea corylifolia | - |
dc.type | Article | - |
dc.citation.title | Food Chemistry | - |
dc.citation.number | 4 | - |
dc.citation.endPage | 945 | - |
dc.citation.startPage | 940 | - |
dc.citation.volume | 121 | - |
dc.contributor.affiliatedAuthor | Woo Song Lee | - |
dc.contributor.alternativeName | 오경렬 | - |
dc.contributor.alternativeName | 이진환 | - |
dc.contributor.alternativeName | Curtis-Long | - |
dc.contributor.alternativeName | 조정근 | - |
dc.contributor.alternativeName | 김준영 | - |
dc.contributor.alternativeName | 이우송 | - |
dc.contributor.alternativeName | 박기훈 | - |
dc.identifier.bibliographicCitation | Food Chemistry, vol. 121, no. 4, pp. 940-945 | - |
dc.identifier.doi | 10.1016/j.foodchem.2010.01.022 | - |
dc.subject.keyword | α-Glucosidase inhibitor | - |
dc.subject.keyword | α-Mannosidase inhibitor | - |
dc.subject.keyword | Glycosidase | - |
dc.subject.keyword | Psoralea corylifolia | - |
dc.subject.local | α-Glucosidase inhibitors | - |
dc.subject.local | α-Glucosidase inhibitor | - |
dc.subject.local | α-glucosidase inhibitor | - |
dc.subject.local | α-Mannosidase inhibitor | - |
dc.subject.local | Glycosidases | - |
dc.subject.local | Glycosidase | - |
dc.subject.local | Psoralea corylifolia L. | - |
dc.subject.local | Psoralea corylifolia | - |
dc.description.journalClass | Y | - |
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