2'-Hydroxycinnamaldehyde shows antitumor activity against oral cancer In vitro and In vivo in a rat tumor model = 구강암에서의 CB-OH의 항암효과

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Title
2'-Hydroxycinnamaldehyde shows antitumor activity against oral cancer In vitro and In vivo in a rat tumor model = 구강암에서의 CB-OH의 항암효과
Author(s)
S A Kim; Y K Sung; Byoung-Mog Kwon; J H Yoon; H Lee; S G Ahn; S H Hong
Bibliographic Citation
Anticancer Research, vol. 30, no. 2, pp. 489-494
Publication Year
2010
Abstract
Background: 2′-Hydroxycinnamaldehyde (HCA) exerts antitumor activity against several human cancer cell lines. However, its antitumor activity in oral cancer has not been demonstrated. Materials and Methods: The antitumor activity of HCA was assessed in oral cancer cell lines and in a rat oral tumor model. Results: Cell cycle analysis confirmed that HCA showed anti-proliferative activity via cell cycle arrest at the G2/M-phase and increased the number of cells in the sub-G1 (apoptotic cells) phase in SCC-15 and HEp-2 oral cancer cells. Additionally, direct injection of HCA into an RK3E-ras-Fluc-induced tumor significantly inhibited growth of the tumor mass. Histological analysis showed that HCA decreased tumor cell proliferation and induced apoptosis in a rat tumor model. Conclusion: Taken together, these observations suggest the potential value of HCA as a candidate for the treatment of oral cancer.
Keyword
2'-HydroxycinnamaldehydeApoptosisCell cycleOral cancerTumor model
ISSN
0250-7005
Publisher
Int Inst Anticancer Research
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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