2'-Hydroxycinnamaldehyde shows antitumor activity against oral cancer In vitro and In vivo in a rat tumor model = 구강암에서의 CB-OH의 항암효과
Cited 0 time in
- 2'-Hydroxycinnamaldehyde shows antitumor activity against oral cancer In vitro and In vivo in a rat tumor model = 구강암에서의 CB-OH의 항암효과
- S A Kim; Y K Sung; Byoung-Mog Kwon; J H Yoon; H Lee; S G Ahn; S H Hong
- Bibliographic Citation
- Anticancer Research, vol. 30, no. 2, pp. 489-494
- Publication Year
- Background: 2′-Hydroxycinnamaldehyde (HCA) exerts antitumor activity against several human cancer cell lines. However, its antitumor activity in oral cancer has not been demonstrated. Materials and Methods: The antitumor activity of HCA was assessed in oral cancer cell lines and in a rat oral tumor model. Results: Cell cycle analysis confirmed that HCA showed anti-proliferative activity via cell cycle arrest at the G2/M-phase and increased the number of cells in the sub-G1 (apoptotic cells) phase in SCC-15 and HEp-2 oral cancer cells. Additionally, direct injection of HCA into an RK3E-ras-Fluc-induced tumor significantly inhibited growth of the tumor mass. Histological analysis showed that HCA decreased tumor cell proliferation and induced apoptosis in a rat tumor model. Conclusion: Taken together, these observations suggest the potential value of HCA as a candidate for the treatment of oral cancer.
- 2'-HydroxycinnamaldehydeApoptosisCell cycleOral cancerTumor model
- Int Inst Anticancer Research
- Appears in Collections:
- 1. Journal Articles > Journal Articles
- Files in This Item:
Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.