Dammarane-type glycosides from gynostemma pentaphyllum and their effects on IL-4-induced eotaxin expression in human bronchial epithelial cells

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Title
Dammarane-type glycosides from gynostemma pentaphyllum and their effects on IL-4-induced eotaxin expression in human bronchial epithelial cells
Author(s)
T M Hung; C V Thu; T D Cuong; N P Hung; S J Kwack; J I Huh; B S Min; J S Choi; Hyeong Kyu Lee; K Bae
Bibliographic Citation
Journal of Natural Products, vol. 73, no. 2, pp. 192-196
Publication Year
2010
Abstract
Two new dammarane-type glycosides, 2α,3β,12β,20S- tetrahydroxydammar-24-ene-3-O-[β-D-glucopyranosyl(1→'4) -sβ-D-glucopyranosyl]-20-O-[β-D-xylopyranosyl-(1→6) -β-D-glucopyranoside] (1) and 2α,3β,12β,20S- tetrahydroxydammar24-ene-3-O-β-D-glucopyranosyl-20-O-[β-D-6-O- acetylglucopyranosyl-(l-→2)-β-D-glucopyranoside] (2), were isolated from a MeOH extract of the leaves of Gynostemma pentaphyllum. Their structures were elucidated by 1D and 2D NMR spectroscopic interpretation as well as by chemical studies. The isolated compounds showed potential inhibitory effects on eotaxin expression in BEAS-2B bronchial epithelial cells.
ISSN
0163-3864
Publisher
Amer Chem Soc
DOI
http://dx.doi.org/10.1021/np9006712
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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