Monitoring of C-reactive protein using ion sensitive field effect transistor biosensor

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dc.contributor.authorH J Park-
dc.contributor.authorS K Kim-
dc.contributor.authorKyoung Sook Park-
dc.contributor.authorSo Yeon Yi-
dc.contributor.authorJ W Chung-
dc.contributor.authorBong Hyun Chung-
dc.contributor.authorMoonil Kim-
dc.date.accessioned2017-04-19T09:18:18Z-
dc.date.available2017-04-19T09:18:18Z-
dc.date.issued2010-
dc.identifier.issn1546-198X-
dc.identifier.uri10.1166/sl.20I0.1248ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9473-
dc.description.abstractAn ion sensitive field effect transistor (ISFET) as a transducer, more precisely an immunologically modified-FET (immuno-FET) device, was utilized for the detection of the C-reactive protein (CRP), a potent marker for inflammation or cardiac risk. The ISFET biosensor investigated in this study was fabricated via a standard CMOS process. Anti-CRP monoclonal antibody was covalently attached to the gate surface using the self-assembled monolayer (SAM) method. The response of anti- CRP antibody to CRP was evaluated via the measurement of the electrical features of the ISFET device. As a consequence, a considerable reduction in drain current was clearly noted upon CRP binding to anti-CRP antibody on the gate, which can be explained by the charge effect, in which negatively charged CRP is predominantly responsible for the current drop in the n-type ISFET. The FET measurement was also verified by surface plasmon resonance (SPR) analysis. Collectively, our data convincingly showed that the FET-type biosensor is potentially applicable to the detection of CRP via antigen-antibody binding events on the gate surface.-
dc.publisherAmerican Scientific Publishersko
dc.titleMonitoring of C-reactive protein using ion sensitive field effect transistor biosensor-
dc.title.alternativeMonitoring of C-reactive protein using ion sensitive field effect transistor biosensor-
dc.typeArticle-
dc.citation.titleSensor Letters-
dc.citation.number2-
dc.citation.endPage237-
dc.citation.startPage233-
dc.citation.volume8-
dc.contributor.affiliatedAuthorKyoung Sook Park-
dc.contributor.affiliatedAuthorSo Yeon Yi-
dc.contributor.affiliatedAuthorBong Hyun Chung-
dc.contributor.affiliatedAuthorMoonil Kim-
dc.contributor.alternativeName박혜정-
dc.contributor.alternativeName김상규-
dc.contributor.alternativeName박경숙-
dc.contributor.alternativeName이소연-
dc.contributor.alternativeName정진웅-
dc.contributor.alternativeName정봉현-
dc.contributor.alternativeName김문일-
dc.identifier.bibliographicCitationSensor Letters, vol. 8, no. 2, pp. 233-237-
dc.identifier.doi10.1166/sl.2010.1248-
dc.subject.keywordAntigen-antibody interaction-
dc.subject.keywordBiosensor-
dc.subject.keywordC-reactive protein-
dc.subject.keywordImmuno-FET-
dc.subject.keywordISFET-
dc.subject.localAntigen-antibody interaction-
dc.subject.localAntigen-Antibody Interaction-
dc.subject.localbiosensor-
dc.subject.localBio-sensor-
dc.subject.localBiosensor-
dc.subject.localbiosensors-
dc.subject.localBiosensors-
dc.subject.localC-reactive protein-
dc.subject.localC-reactive protein (CRP)-
dc.subject.localImmuno-FET-
dc.subject.localISFET-
dc.description.journalClassN-
Appears in Collections:
Critical Diseases Diagnostics Convergence Research Center > 1. Journal Articles
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