Bioactive metabolites from the sponge-derived fungus Aspergillus versicolor

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dc.contributor.authorY M Lee-
dc.contributor.authorH Li-
dc.contributor.authorJ Hong-
dc.contributor.authorH Y Cho-
dc.contributor.authorKyung Sook Bae-
dc.contributor.authorM A Kim-
dc.contributor.authorD K Kim-
dc.contributor.authorJ H Jung-
dc.date.accessioned2017-04-19T09:18:19Z-
dc.date.available2017-04-19T09:18:19Z-
dc.date.issued2010-
dc.identifier.issn02536269-
dc.identifier.uri10.1007/s12272-010-0207-4ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9481-
dc.description.abstractAs part of an ongoing search for bioactive metabolites from the fungus Aspergillus versicolor derived from a marine sponge Petrosia sp., an aromatic polyketide derivative (1), two xanthones (2 and 3), and five anthraquinones (4-8) were isolated by bioactivity-guided fractionation. The gross structures were determined based on the NMR and MS spectroscopic data, and the absolute configurations were defined by comparison of optical rotation data with those of reported. Compounds 2, 4, 5, and 7 exhibited significant cytotoxicity against five human solid tumor cell lines (A-549, SK-OV-3, SK-MEL-2, XF-498, and HCT-15) with IC50 values in the range of 0.41-4.61 μg/mL. Compounds 4 and 7 exhibited antibacterial activity against several clinically isolated Gram-positive strains with MIC values of 0.78-6.25 μg/mL.-
dc.publisherPharmaceutical Soc Korea-
dc.titleBioactive metabolites from the sponge-derived fungus Aspergillus versicolor-
dc.title.alternativeBioactive metabolites from the sponge-derived fungus Aspergillus versicolor-
dc.typeArticle-
dc.citation.titleArchives of Pharmacal Research-
dc.citation.number2-
dc.citation.endPage235-
dc.citation.startPage231-
dc.citation.volume33-
dc.contributor.alternativeName-
dc.contributor.alternativeName-
dc.contributor.alternativeName-
dc.contributor.alternativeName-
dc.contributor.alternativeName배경숙-
dc.contributor.alternativeName-
dc.contributor.alternativeName-
dc.contributor.alternativeName-
dc.identifier.bibliographicCitationArchives of Pharmacal Research, vol. 33, no. 2, pp. 231-235-
dc.identifier.doi10.1007/s12272-010-0207-4-
dc.subject.keywordAnthraquinone-
dc.subject.keywordAntibacterial activity-
dc.subject.keywordAspergillus versicolor-
dc.subject.keywordCytotoxicity-
dc.subject.keywordPolyketide-
dc.subject.keywordXanthone-
dc.subject.localAnthraquinone-
dc.subject.localAntibacterial activity-
dc.subject.localAspergillus versicolor-
dc.subject.localCytotoxicity-
dc.subject.localPolyketide-
dc.subject.localXanthone-
dc.description.journalClassY-
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