TXNIP regulates germinal center generation by suppressing BCL-6 expression

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dc.contributor.authorY Shao-
dc.contributor.authorS Y Kim-
dc.contributor.authorD Shin-
dc.contributor.authorMi-Sun Kim-
dc.contributor.authorHyun-Woo Suh-
dc.contributor.authorZ H Piao-
dc.contributor.authorM Jeong-
dc.contributor.authorSuk Hyung Lee-
dc.contributor.authorSuk Ran Yoon-
dc.contributor.authorB H Lim-
dc.contributor.authorW H Kim-
dc.contributor.authorJ K Ahn-
dc.contributor.authorIn Pyo Choi-
dc.date.accessioned2017-04-19T09:18:20Z-
dc.date.available2017-04-19T09:18:20Z-
dc.date.issued2010-
dc.identifier.issn01652478-
dc.identifier.uri10.1016/j.imlet.2010.02.002ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9482-
dc.description.abstractThe detailed mechanism driving the germinal center (GC) reaction to B cell lymphomagenesis has not been clarified. Thioredoxin interacting protein (TXNIP), also known as vitamin D3 up-regulated protein 1 which is an important tumor repressor, is involved in stress responses, redox regulation, and cellular proliferation. Here, we report that TXNIP has a potential role in the formation of GC in peripheral lymphoid organs where B lymphocytes divide rapidly. First, we compared changes in GC from wild type mice and Txnip-/- mice. After immunization, Txnip-/- mice exhibited higher expression level of BCL-6 and larger percentage of GC B cells with the reduction in antibody production and plasma cell numbers. In addition, Txnip-/- spleens had a much larger population which expressed Ki-67, a marker of cell proliferation, in the red pulp border than WT spleens. Furthermore, the expression of BCL-6 was decreased in TXNIP overexpressing cells and elevated in TXNIP deficient cells. Taken together, we conclude that TXNIP may contribute to the formation of GCs after immunization. During this process, TXNIP suppresses BCL-6 expression.-
dc.publisherElsevier-
dc.titleTXNIP regulates germinal center generation by suppressing BCL-6 expression-
dc.title.alternativeTXNIP regulates germinal center generation by suppressing BCL-6 expression-
dc.typeArticle-
dc.citation.titleImmunology Letters-
dc.citation.number2-
dc.citation.endPage84-
dc.citation.startPage78-
dc.citation.volume129-
dc.contributor.affiliatedAuthorSuk Ran Yoon-
dc.contributor.affiliatedAuthorIn Pyo Choi-
dc.contributor.alternativeNameShao-
dc.contributor.alternativeName김상용-
dc.contributor.alternativeName신대성-
dc.contributor.alternativeName김미선-
dc.contributor.alternativeName서현우-
dc.contributor.alternativeNamePiao-
dc.contributor.alternativeName정미라-
dc.contributor.alternativeName이석형-
dc.contributor.alternativeName윤석란-
dc.contributor.alternativeName임병호-
dc.contributor.alternativeName김우호-
dc.contributor.alternativeName안정근-
dc.contributor.alternativeName최인표-
dc.identifier.bibliographicCitationImmunology Letters, vol. 129, no. 2, pp. 78-84-
dc.identifier.doi10.1016/j.imlet.2010.02.002-
dc.subject.keywordB cells-
dc.subject.keywordBCL-6-
dc.subject.keywordGerminal center-
dc.subject.keywordTXNIP-
dc.subject.localB cells-
dc.subject.localB cell-
dc.subject.localBCL-6-
dc.subject.localGerminal center-
dc.subject.localGerminal center (GC)-
dc.subject.localTXNIP-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
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