DC Field | Value | Language |
---|---|---|
dc.contributor.author | Y L Wu | - |
dc.contributor.author | Y Z Jiang | - |
dc.contributor.author | X J Jin | - |
dc.contributor.author | L H Lian | - |
dc.contributor.author | J Y Piao | - |
dc.contributor.author | Y Wan | - |
dc.contributor.author | H R Jin | - |
dc.contributor.author | Jung Joon Lee | - |
dc.contributor.author | J X Nan | - |
dc.date.accessioned | 2017-04-19T09:18:21Z | - |
dc.date.available | 2017-04-19T09:18:21Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0944-7113 | - |
dc.identifier.uri | 10.1016/j.phymed.2009.07.011 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/9487 | - |
dc.description.abstract | The protective effect of a diterpenoid acanthoic acid (AA) isolated from Acanthopanax koreanum Nakai was investigated in acetaminophen (APAP)-induced hepatic toxicity. Drug-induced hepatotoxicity induced by an intraperitoneal (i.p.) injection of 300 mg/kg (sub-lethal dose) of APAP. Pretreatment with AA (50 and 100 mg/kg) orally 2 h before the APAP administration attenuated the APAP-induced acute increase in serum aspartate aminotransferase (AST), and alanine aminotransferase (ALT) activites, replenished the depleted hepatic glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) activities, decreased malondialdehyde (MDA) level and considerably reduced the histopathological alterations in a manner similar to silymarin (Sily). Immunohistochemical analyses also demonstrated that AA could reduce the appearance of necrosis regions as well as caspase-3 and hypoxia inducible factor-1α (HIF-1α) expression in liver tissue. Our results indicated that AA protected liver tissue from the oxidative stress elicites by APAP-induced liver damage and suggestes that the hepatic protection mechanism of AA would relate to antioxidation and hypoxia factor on APAP-induced hepatotoxicity. | - |
dc.publisher | Elsevier | - |
dc.title | Acanthoic acid, a diterpene in Acanthopanax koreanum, protects acetaminophen-induced hepatic toxicity in mice | - |
dc.title.alternative | Acanthoic acid, a diterpene in Acanthopanax koreanum, protects acetaminophen-induced hepatic toxicity in mice | - |
dc.type | Article | - |
dc.citation.title | Phytomedicine | - |
dc.citation.number | 6 | - |
dc.citation.endPage | 479 | - |
dc.citation.startPage | 475 | - |
dc.citation.volume | 17 | - |
dc.contributor.affiliatedAuthor | Jung Joon Lee | - |
dc.contributor.alternativeName | Wu | - |
dc.contributor.alternativeName | Jiang | - |
dc.contributor.alternativeName | Jin | - |
dc.contributor.alternativeName | Lian | - |
dc.contributor.alternativeName | Piao | - |
dc.contributor.alternativeName | Wan | - |
dc.contributor.alternativeName | Jin | - |
dc.contributor.alternativeName | 이정준 | - |
dc.contributor.alternativeName | Nan | - |
dc.identifier.bibliographicCitation | Phytomedicine, vol. 17, no. 6, pp. 475-479 | - |
dc.identifier.doi | 10.1016/j.phymed.2009.07.011 | - |
dc.subject.keyword | Acanthoic acid | - |
dc.subject.keyword | Acanthopanax koreanum | - |
dc.subject.keyword | Acetaminophen | - |
dc.subject.keyword | Antioxidation | - |
dc.subject.keyword | Hepatotoxicity | - |
dc.subject.keyword | Hypoxia inducible factor-1α | - |
dc.subject.local | Acanthoic acid | - |
dc.subject.local | Acanthopanax koreanum | - |
dc.subject.local | acanthopanax koreanum | - |
dc.subject.local | Acetaminophen | - |
dc.subject.local | antioxidation | - |
dc.subject.local | Antioxidation | - |
dc.subject.local | Anti-oxidation | - |
dc.subject.local | hepatotoxicity | - |
dc.subject.local | Hepatotoxicity | - |
dc.subject.local | hypoxia-inducible factor 1α | - |
dc.subject.local | Hypoxia-inducible factor-1α | - |
dc.subject.local | hypoxia inducible factor-1α (HIF-1α) | - |
dc.subject.local | hypoxia-inducible factor-1α | - |
dc.subject.local | Hypoxia inducible factor-1α | - |
dc.subject.local | Hypoxic inducible factor-1a | - |
dc.subject.local | Hypoxia-inducible factor 1 alpha | - |
dc.description.journalClass | Y | - |
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