Acanthoic acid, a diterpene in Acanthopanax koreanum, protects acetaminophen-induced hepatic toxicity in mice

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dc.contributor.authorY L Wu-
dc.contributor.authorY Z Jiang-
dc.contributor.authorX J Jin-
dc.contributor.authorL H Lian-
dc.contributor.authorJ Y Piao-
dc.contributor.authorY Wan-
dc.contributor.authorH R Jin-
dc.contributor.authorJung Joon Lee-
dc.contributor.authorJ X Nan-
dc.date.accessioned2017-04-19T09:18:21Z-
dc.date.available2017-04-19T09:18:21Z-
dc.date.issued2010-
dc.identifier.issn0944-7113-
dc.identifier.uri10.1016/j.phymed.2009.07.011ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9487-
dc.description.abstractThe protective effect of a diterpenoid acanthoic acid (AA) isolated from Acanthopanax koreanum Nakai was investigated in acetaminophen (APAP)-induced hepatic toxicity. Drug-induced hepatotoxicity induced by an intraperitoneal (i.p.) injection of 300 mg/kg (sub-lethal dose) of APAP. Pretreatment with AA (50 and 100 mg/kg) orally 2 h before the APAP administration attenuated the APAP-induced acute increase in serum aspartate aminotransferase (AST), and alanine aminotransferase (ALT) activites, replenished the depleted hepatic glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) activities, decreased malondialdehyde (MDA) level and considerably reduced the histopathological alterations in a manner similar to silymarin (Sily). Immunohistochemical analyses also demonstrated that AA could reduce the appearance of necrosis regions as well as caspase-3 and hypoxia inducible factor-1α (HIF-1α) expression in liver tissue. Our results indicated that AA protected liver tissue from the oxidative stress elicites by APAP-induced liver damage and suggestes that the hepatic protection mechanism of AA would relate to antioxidation and hypoxia factor on APAP-induced hepatotoxicity.-
dc.publisherElsevier-
dc.titleAcanthoic acid, a diterpene in Acanthopanax koreanum, protects acetaminophen-induced hepatic toxicity in mice-
dc.title.alternativeAcanthoic acid, a diterpene in Acanthopanax koreanum, protects acetaminophen-induced hepatic toxicity in mice-
dc.typeArticle-
dc.citation.titlePhytomedicine-
dc.citation.number6-
dc.citation.endPage479-
dc.citation.startPage475-
dc.citation.volume17-
dc.contributor.affiliatedAuthorJung Joon Lee-
dc.contributor.alternativeNameWu-
dc.contributor.alternativeNameJiang-
dc.contributor.alternativeNameJin-
dc.contributor.alternativeNameLian-
dc.contributor.alternativeNamePiao-
dc.contributor.alternativeNameWan-
dc.contributor.alternativeNameJin-
dc.contributor.alternativeName이정준-
dc.contributor.alternativeNameNan-
dc.identifier.bibliographicCitationPhytomedicine, vol. 17, no. 6, pp. 475-479-
dc.identifier.doi10.1016/j.phymed.2009.07.011-
dc.subject.keywordAcanthoic acid-
dc.subject.keywordAcanthopanax koreanum-
dc.subject.keywordAcetaminophen-
dc.subject.keywordAntioxidation-
dc.subject.keywordHepatotoxicity-
dc.subject.keywordHypoxia inducible factor-1α-
dc.subject.localAcanthoic acid-
dc.subject.localAcanthopanax koreanum-
dc.subject.localacanthopanax koreanum-
dc.subject.localAcetaminophen-
dc.subject.localantioxidation-
dc.subject.localAntioxidation-
dc.subject.localAnti-oxidation-
dc.subject.localhepatotoxicity-
dc.subject.localHepatotoxicity-
dc.subject.localhypoxia-inducible factor 1α-
dc.subject.localHypoxia-inducible factor-1α-
dc.subject.localhypoxia inducible factor-1α (HIF-1α)-
dc.subject.localhypoxia-inducible factor-1α-
dc.subject.localHypoxia inducible factor-1α-
dc.subject.localHypoxic inducible factor-1a-
dc.subject.localHypoxia-inducible factor 1 alpha-
dc.description.journalClassY-
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