Four different ways of alternative transcripts generation mechanism in ADRA1A gene = ADRA1A 유전자의 4개의 alternative 전사체의 생성 기작

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dc.contributor.authorJae Won Huh-
dc.contributor.authorYoung-Hyun Kim-
dc.contributor.authorSang Rae Lee-
dc.contributor.authorDae Soo Kim-
dc.contributor.authorSang Je Park-
dc.contributor.authorH Kim-
dc.contributor.authorJi Su Kim-
dc.contributor.authorBong Seok Song-
dc.contributor.authorH S Kim-
dc.contributor.authorKyu Tae Chang-
dc.date.accessioned2017-04-19T09:18:23Z-
dc.date.available2017-04-19T09:18:23Z-
dc.date.issued2010-
dc.identifier.issn13417568-
dc.identifier.uri10.1266/ggs.85.65ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9495-
dc.description.abstractThe ADRA1A (Alpha-1-adrenergic receptor) gene is one of the members of G protein-coupled receptor superfamily. Alternative splicing of this gene was known to generate four transcript variants which code four isoforms with various C-terminal regions. In this study, we conducted expression analysis and evolu- tionary characterization of alternative transcripts of the ADRA1A gene. In total, 10 alternative transcripts were identified using experimental approaches and in silico analysis. Among them, 6 alternative transcripts (T1, T2, T3, T4, T4-1, and T8) were validated by RT-PCR approaches and sequencing procedures. From the alternative splicing analysis, it could be assumed that there were three different alternative transcripts generation mechanisms and unknown mechanism. First one is the integration event of three different TEs (AluSc, L1MC5, and MIR3) as seen on the last exons of T3, T4, T4-1, T5, T6, and T7 transcripts. The second mechanism is a differential promoter usage on T8. The third one is a substitution event of the 3' splicing site during the primate evolution on T3. The last one is an unknown mechanism which was identified in the T4-1 transcript. Therefore, alternative transcripts of human ADRA1A gene occurred by four different ways, such as integration of TEs, differential promoter usage, substitution of splicing sites, and unknown mechanism.-
dc.publisherGenetics Soc Japan-
dc.titleFour different ways of alternative transcripts generation mechanism in ADRA1A gene = ADRA1A 유전자의 4개의 alternative 전사체의 생성 기작-
dc.title.alternativeFour different ways of alternative transcripts generation mechanism in ADRA1A gene-
dc.typeArticle-
dc.citation.titleGenes & Genetic Systems-
dc.citation.number1-
dc.citation.endPage73-
dc.citation.startPage65-
dc.citation.volume85-
dc.contributor.affiliatedAuthorJae Won Huh-
dc.contributor.affiliatedAuthorYoung-Hyun Kim-
dc.contributor.affiliatedAuthorSang Rae Lee-
dc.contributor.affiliatedAuthorDae Soo Kim-
dc.contributor.affiliatedAuthorSang Je Park-
dc.contributor.affiliatedAuthorJi Su Kim-
dc.contributor.affiliatedAuthorBong Seok Song-
dc.contributor.alternativeName허재원-
dc.contributor.alternativeName김영현-
dc.contributor.alternativeName이상래-
dc.contributor.alternativeName김대수-
dc.contributor.alternativeName박상제-
dc.contributor.alternativeName김형우-
dc.contributor.alternativeName김지수-
dc.contributor.alternativeName송봉석-
dc.contributor.alternativeName김희수-
dc.contributor.alternativeName장규태-
dc.identifier.bibliographicCitationGenes & Genetic Systems, vol. 85, no. 1, pp. 65-73-
dc.identifier.doi10.1266/ggs.85.65-
dc.subject.keywordAdra1a gene-
dc.subject.keywordAlternative splicing-
dc.subject.keywordSubstitution-
dc.subject.keywordTes integration-
dc.subject.localAdra1a gene-
dc.subject.localAlternative splicing-
dc.subject.localSubstitution-
dc.subject.localTes integration-
dc.description.journalClassY-
Appears in Collections:
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Division of Research on National Challenges > Environmental diseases research center > 1. Journal Articles
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Ochang Branch Institute > Division of Bioinfrastructure > Futuristic Animal Resource & Research Center > 1. Journal Articles
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