DC Field | Value | Language |
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dc.contributor.author | S J An | - |
dc.contributor.author | J I Han | - |
dc.contributor.author | M J Kim | - |
dc.contributor.author | J S Park | - |
dc.contributor.author | Jong Min Han | - |
dc.contributor.author | N I Baek | - |
dc.contributor.author | H G Chung | - |
dc.contributor.author | M S Choi | - |
dc.contributor.author | K T Lee | - |
dc.contributor.author | Tae Sook Jeong | - |
dc.date.accessioned | 2017-04-19T09:18:24Z | - |
dc.date.available | 2017-04-19T09:18:24Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 1096-620X | - |
dc.identifier.uri | 10.1089/jmf.2009.1295. | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/9496 | - |
dc.description.abstract | The influence of ethanolic extracts of Brassica campestris spp. rapa roots (EBR) on obesity was examined in imprinting control region (ICR) mice fed a high-fat diet (HFD) and in 3T3-L1 adipocytes. The ICR mice used were divided into regular diet, HFD, EBR (50 mg/kg/day EBR administered orally), and orlistat (10 mg/kg/day orlistat administered orally) groups. The molecular mechanism of the anti-obesity effect of EBR was investigated in 3T3-L1 adipocytes as well as in HFD-fed ICR mice. In the obese mouse model, both weight gain and epididymal fat accumulation were highly suppressed by the daily oral administration of 50 mg/kg EBR for 8 weeks, whereas the overall amount of food intake was not affected. EBR treatment induced the expression in white adipocytes of lipolysis-related genes, including beta(3)-adrenergic receptor (beta(3)-AR), hormone-sensitive lipase (HSL), adipose triglyceride lipase, and uncoupling protein 2. Furthermore, the activation of cyclic AMP-dependent protein kinase, HSL, and extracellular signal-regulated kinase was induced in EBR-treated 3T3-L1 cells. The lipolytic effect of EBR involved beta(3)-AR modulation, as inferred from the inhibition by the beta(3)-AR antagonist propranolol. These results suggest that EBR may have potential as a safe and effective anti-obesity agent via the inhibition of adipocyte lipid accumulation and the stimulation of beta(3)-AR-dependent lipolysis. | - |
dc.publisher | Mary Ann Liebert, Inc | - |
dc.title | Ethanolic extracts of Brassica campestris spp. rapa roots prevent high-fat diet-induced obesity via beta(3)-adrenergic regulation of white adipocyte lipolytic activity = 순무 에탄올추출물의 항비만 효능 | - |
dc.title.alternative | Ethanolic extracts of Brassica campestris spp. rapa roots prevent high-fat diet-induced obesity via beta(3)-adrenergic regulation of white adipocyte lipolytic activity | - |
dc.type | Article | - |
dc.citation.title | Journal of Medicinal Food | - |
dc.citation.number | 2 | - |
dc.citation.endPage | 414 | - |
dc.citation.startPage | 406 | - |
dc.citation.volume | 13 | - |
dc.contributor.affiliatedAuthor | Jong Min Han | - |
dc.contributor.affiliatedAuthor | Tae Sook Jeong | - |
dc.contributor.alternativeName | 안소진 | - |
dc.contributor.alternativeName | 한장일 | - |
dc.contributor.alternativeName | 김민정 | - |
dc.contributor.alternativeName | 박지선 | - |
dc.contributor.alternativeName | 한종민 | - |
dc.contributor.alternativeName | 백남인 | - |
dc.contributor.alternativeName | 정해곤 | - |
dc.contributor.alternativeName | 최명숙 | - |
dc.contributor.alternativeName | 이경태 | - |
dc.contributor.alternativeName | 정태숙 | - |
dc.identifier.bibliographicCitation | Journal of Medicinal Food, vol. 13, no. 2, pp. 406-414 | - |
dc.identifier.doi | 10.1089/jmf.2009.1295 | - |
dc.subject.keyword | b3-adrenegic receptor | - |
dc.subject.keyword | anti-obesity effect | - |
dc.subject.keyword | Brassica campestris spp. Rapa | - |
dc.subject.keyword | lipolysis | - |
dc.subject.keyword | white adipose tissue | - |
dc.subject.local | b3-adrenegic receptor | - |
dc.subject.local | anti-obesity effect | - |
dc.subject.local | Anti-obesity effect | - |
dc.subject.local | Brassica campestris spp. Rapa | - |
dc.subject.local | brassica campestris ssp rapa | - |
dc.subject.local | lipolysis | - |
dc.subject.local | white adipose tissue | - |
dc.subject.local | white adipose tissue (WAT) | - |
dc.subject.local | White adipose tissue | - |
dc.description.journalClass | Y | - |
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