Ethanolic extracts of Brassica campestris spp. rapa roots prevent high-fat diet-induced obesity via beta(3)-adrenergic regulation of white adipocyte lipolytic activity = 순무 에탄올추출물의 항비만 효능

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dc.contributor.authorS J An-
dc.contributor.authorJ I Han-
dc.contributor.authorM J Kim-
dc.contributor.authorJ S Park-
dc.contributor.authorJong Min Han-
dc.contributor.authorN I Baek-
dc.contributor.authorH G Chung-
dc.contributor.authorM S Choi-
dc.contributor.authorK T Lee-
dc.contributor.authorTae Sook Jeong-
dc.date.accessioned2017-04-19T09:18:24Z-
dc.date.available2017-04-19T09:18:24Z-
dc.date.issued2010-
dc.identifier.issn1096-620X-
dc.identifier.uri10.1089/jmf.2009.1295.ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9496-
dc.description.abstractThe influence of ethanolic extracts of Brassica campestris spp. rapa roots (EBR) on obesity was examined in imprinting control region (ICR) mice fed a high-fat diet (HFD) and in 3T3-L1 adipocytes. The ICR mice used were divided into regular diet, HFD, EBR (50 mg/kg/day EBR administered orally), and orlistat (10 mg/kg/day orlistat administered orally) groups. The molecular mechanism of the anti-obesity effect of EBR was investigated in 3T3-L1 adipocytes as well as in HFD-fed ICR mice. In the obese mouse model, both weight gain and epididymal fat accumulation were highly suppressed by the daily oral administration of 50 mg/kg EBR for 8 weeks, whereas the overall amount of food intake was not affected. EBR treatment induced the expression in white adipocytes of lipolysis-related genes, including beta(3)-adrenergic receptor (beta(3)-AR), hormone-sensitive lipase (HSL), adipose triglyceride lipase, and uncoupling protein 2. Furthermore, the activation of cyclic AMP-dependent protein kinase, HSL, and extracellular signal-regulated kinase was induced in EBR-treated 3T3-L1 cells. The lipolytic effect of EBR involved beta(3)-AR modulation, as inferred from the inhibition by the beta(3)-AR antagonist propranolol. These results suggest that EBR may have potential as a safe and effective anti-obesity agent via the inhibition of adipocyte lipid accumulation and the stimulation of beta(3)-AR-dependent lipolysis.-
dc.publisherMary Ann Liebert, Inc-
dc.titleEthanolic extracts of Brassica campestris spp. rapa roots prevent high-fat diet-induced obesity via beta(3)-adrenergic regulation of white adipocyte lipolytic activity = 순무 에탄올추출물의 항비만 효능-
dc.title.alternativeEthanolic extracts of Brassica campestris spp. rapa roots prevent high-fat diet-induced obesity via beta(3)-adrenergic regulation of white adipocyte lipolytic activity-
dc.typeArticle-
dc.citation.titleJournal of Medicinal Food-
dc.citation.number2-
dc.citation.endPage414-
dc.citation.startPage406-
dc.citation.volume13-
dc.contributor.affiliatedAuthorJong Min Han-
dc.contributor.affiliatedAuthorTae Sook Jeong-
dc.contributor.alternativeName안소진-
dc.contributor.alternativeName한장일-
dc.contributor.alternativeName김민정-
dc.contributor.alternativeName박지선-
dc.contributor.alternativeName한종민-
dc.contributor.alternativeName백남인-
dc.contributor.alternativeName정해곤-
dc.contributor.alternativeName최명숙-
dc.contributor.alternativeName이경태-
dc.contributor.alternativeName정태숙-
dc.identifier.bibliographicCitationJournal of Medicinal Food, vol. 13, no. 2, pp. 406-414-
dc.identifier.doi10.1089/jmf.2009.1295-
dc.subject.keywordb3-adrenegic receptor-
dc.subject.keywordanti-obesity effect-
dc.subject.keywordBrassica campestris spp. Rapa-
dc.subject.keywordlipolysis-
dc.subject.keywordwhite adipose tissue-
dc.subject.localb3-adrenegic receptor-
dc.subject.localanti-obesity effect-
dc.subject.localbrassica campestris ssp rapa-
dc.subject.localBrassica campestris spp. Rapa-
dc.subject.locallipolysis-
dc.subject.localWhite adipose tissue-
dc.subject.localwhite adipose tissue-
dc.subject.localwhite adipose tissue (WAT)-
dc.description.journalClassY-
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Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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