Efficient revascularization by VEGF administration via heparin-functionalized nanoparticle-fibrin complex

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Title
Efficient revascularization by VEGF administration via heparin-functionalized nanoparticle-fibrin complex
Author(s)
Y I Chung; S K Kim; Y K Lee; Su-Jin Park; K O Cho; S H Yuk; G Tae; Y H Kim
Bibliographic Citation
Journal of Controlled Release, vol. 143, no. 3, pp. 282-289
Publication Year
2010
Abstract
We investigated the angiogenic bioactivity and therapeutic angiogenic effect of vascular endothelial growth factor (VEGF) administration by the heparin-functionalized nanoparticle-fibrin gel complex. The markedly increased bioactivity was observed by the VEGF-loaded nanoparticle-fibrin gel complex, compared to the VEGF-loaded fibrin gel, the nanoparticle-fibrin gel complex without VEGF, or fibrin gel (control) in terms of the capillary density in a mouse subcutaneous implantation model. Furthermore, the VEGF-loaded nanoparticle-fibrin gel complex significantly enhanced the therapeutic angiogenic effect in a rabbit ischemic hind limb model: the noticeable increase in the recovered calf blood pressure, the angiographic score, and the density of collaterals, as well as the stable maintenance of the organized collaterals, compared to the VEGF-loaded fibrin gel. These results show the enhanced angiogenic potential of VEGF administration by the proposed heparin-functionalized nanoparticle-fibrin gel complex.
Keyword
AngiogenesisControlled releaseFibrinGrowth factorsHeparin
ISSN
0168-3659
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.jconrel.2010.01.010
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
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