Transcriptional regulation of the rsbV promoter controlling stress responses to ethanol, carbon limitation, and phosphorous limitation in Bacillus subtilis = 고초균에서 rsbV 프로모터의 전사조절

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Title
Transcriptional regulation of the rsbV promoter controlling stress responses to ethanol, carbon limitation, and phosphorous limitation in Bacillus subtilis = 고초균에서 rsbV 프로모터의 전사조절
Author(s)
Soo Keun Choi; M H Saier
Bibliographic Citation
International Journal of Microbiology, vol. 2010, pp. 263410-263410
Publication Year
2010
Abstract
The sigma(B)-dependent promoter in front of the rsbV gene of Bacillus subtilis is induced approximately 5-fold in response to (1) the addition of 4% ethanol, (2) carbon starvation, and (3) phosphorous starvation. Binding sites for the global carbon and nitrogen regulators, CcpA and TnrA, were mutated, and the consequences of their loss and that of CcpA or TnrA were studied using rsbV-lacZ fusions. These responses proved to be dependent on CcpA, TnrA, and their putative binding sites upstream of the promoter. Induction in response to glucose limitation was largely abolished by loss of CcpA or the upstream region, while induction in response to phosphorous limitation was largely abolished only by the upstream mutations. The results suggest that CcpA directly influences the carbon starvation response and that both proteins exert indirect effects on all three stress responses. The integrity of the DNA sequence is important for all three responses.
ISSN
1687-918X
Publisher
Hindawi Publishing Corporation
DOI
http://dx.doi.org/10.1155/2010/263410
Type
Article
Appears in Collections:
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
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