Identification of autoantibody against fatty acid synthase in hepatocellular carcinoma mouse model and its application to diagnosis of HCC

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dc.contributor.authorChang Gyu Heo-
dc.contributor.authorMi-Kyung Woo-
dc.contributor.authorDae Yeul Yu-
dc.contributor.authorJ Y Lee-
dc.contributor.authorJ S Yoo-
dc.contributor.authorHyang Sook Yoo-
dc.contributor.authorJeong Heon Ko-
dc.contributor.authorJ M Kim-
dc.contributor.authorJ Y Choi-
dc.contributor.authorI G Kim-
dc.contributor.authorS G Paik-
dc.contributor.authorEun Wie Cho-
dc.date.accessioned2017-04-19T09:18:32Z-
dc.date.available2017-04-19T09:18:32Z-
dc.date.issued2010-
dc.identifier.issn1019-6439-
dc.identifier.uri10.3892/ijo-00000631ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9510-
dc.description.abstractAutoantibodies, which are generated by immune system recognizing the presence of the abnormal tumor-associated antigens, are promising biomarkers for early detection of tumors. Recently, we established a B cell hybridoma pool derived from H-ras12V transgenic mouse, a typical hepatocellular carcinoma model, as a source of tumor-associated autoantibodies without using any extracellular antigens and have characterized the specific target antigens against them. K1 autoantibody, one of them, was investigated in this study and its target antigen was identified by mass spectrometric analysis as fatty acid synthase (FASN), an important oncogenic protein. Moreover, a specific mimotope against K1 autoantibody was screened from the cyclic random hepta-peptide phage library and, using it as a coating antigen for ELISA, we could distinguish patients with hepatocellular carcinoma (HCC) vs. normal subjects with 96.55% sensitivity and 100% specificity. These results imply that anti-FASN autoantibody is induced in patients with HCC and detection of anti-FASN autoantibody can be used for the diagnosis of HCC.-
dc.publisherSpandidos Publ Ltd-
dc.titleIdentification of autoantibody against fatty acid synthase in hepatocellular carcinoma mouse model and its application to diagnosis of HCC-
dc.title.alternativeIdentification of autoantibody against fatty acid synthase in hepatocellular carcinoma mouse model and its application to diagnosis of HCC-
dc.typeArticle-
dc.citation.titleInternational Journal of Oncology-
dc.citation.number6-
dc.citation.endPage1459-
dc.citation.startPage1453-
dc.citation.volume36-
dc.contributor.affiliatedAuthorChang Gyu Heo-
dc.contributor.affiliatedAuthorMi-Kyung Woo-
dc.contributor.affiliatedAuthorDae Yeul Yu-
dc.contributor.affiliatedAuthorHyang Sook Yoo-
dc.contributor.affiliatedAuthorJeong Heon Ko-
dc.contributor.affiliatedAuthorEun Wie Cho-
dc.contributor.alternativeName허창규-
dc.contributor.alternativeName우미경-
dc.contributor.alternativeName유대열-
dc.contributor.alternativeName이주연-
dc.contributor.alternativeName유종신-
dc.contributor.alternativeName유향숙-
dc.contributor.alternativeName고정헌-
dc.contributor.alternativeName김진만-
dc.contributor.alternativeName최종영-
dc.contributor.alternativeName김인규-
dc.contributor.alternativeName백상기-
dc.contributor.alternativeName조은위-
dc.identifier.bibliographicCitationInternational Journal of Oncology, vol. 36, no. 6, pp. 1453-1459-
dc.identifier.doi10.3892/ijo-00000631-
dc.subject.keywordFatty acid synthase-
dc.subject.keywordH-ras12V mouse-
dc.subject.keywordHepatocellular carcinoma-
dc.subject.keywordTumor-associated autoantibody-
dc.subject.localFatty acid synthase (FAS)-
dc.subject.localFatty acid synthase-
dc.subject.localH-ras12V mouse-
dc.subject.localHepatocellular carcinomas-
dc.subject.localHepatocellular carcinoma (HCC)-
dc.subject.localHepatocellular carcinoma-
dc.subject.localhepatocellular carcinoma (HCC)-
dc.subject.localhepatocellular carcinoma-
dc.subject.localTumor-associated autoantibody-
dc.description.journalClassY-
Appears in Collections:
Synthetic Biology and Bioengineering Research Institute > Genome Editing Research Center > 1. Journal Articles
Division of Biomedical Research > Rare Disease Research Center > 1. Journal Articles
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