An iminocoumarin-based fluorescent probe for the selective detection of dual-specific protein tyrosine phosphatases = 이중특이성 PTP의 선택적 검출을 위한 이미노쿠마린 형광탐침

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Title
An iminocoumarin-based fluorescent probe for the selective detection of dual-specific protein tyrosine phosphatases = 이중특이성 PTP의 선택적 검출을 위한 이미노쿠마린 형광탐침
Author(s)
T I Kim; Myung Sun Jung; Sang Jeon Chung; Y Kim
Bibliographic Citation
Chemistry-A European Journal, vol. 16, no. 18, pp. 5297-5300
Publication Year
2010
Abstract
(Figure Presented) Seeing is believing: A fluorescent probe for monitoring the activity of dual-specific protein tyrosine phosphatases (PTPs) has been developed (see scheme). Selective enzymatic hydrolysis and subsequent intramolecular cyclization results in a highly fluorescent iminocoumarin fluorophore.
Keyword
CyclizationDual specificityFluorescent probesProtein tyrosine phosphatases
ISSN
0947-6539
Publisher
Wiley
DOI
http://dx.doi.org/10.1002/chem.201000154
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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