An iminocoumarin-based fluorescent probe for the selective detection of dual-specific protein tyrosine phosphatases = 이중특이성 PTP의 선택적 검출을 위한 이미노쿠마린 형광탐침

Abstract

(Figure Presented) Seeing is believing: A fluorescent probe for monitoring the activity of dual-specific protein tyrosine phosphatases (PTPs) has been developed (see scheme). Selective enzymatic hydrolysis and subsequent intramolecular cyclization results in a highly fluorescent iminocoumarin fluorophore.