Melanogenesis inhibitory effect of dehydroevodiamine isolated from fruits of Evodia rutaecarpa = Dehydroevodiamine의 미백활성

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Title
Melanogenesis inhibitory effect of dehydroevodiamine isolated from fruits of Evodia rutaecarpa = Dehydroevodiamine의 미백활성
Author(s)
L H Luo; Jeong Woo Seo; D H Nguyen; E K Kim; S A Kang; D H Kim; Chul Ho Kim
Bibliographic Citation
Korean Journal of Chemical Engineering, vol. 27, no. 3, pp. 915-918
Publication Year
2010
Abstract
Dehydroevodiamine, an alkaloid, was isolated from the fruit of Evodia rutaecarpa and melanin production, and tyrosinase inhibition in B16F10 melanoma cells treated with the isolated dehydroevodiamine was investigated. The compound decreased melanin synthesis significantly without promoting cytotoxicity. The IC50 value of dehydroevodiamine for melanogenesis and cell viability were 59.8 μM and 90.0 μM, respectively. The L-dopa oxidase activity of mushroom tyrosinase was reduced after dehydroevodiamine treatment by about 22.4% at a concentration of 33.2 μM. However, there was no effect on cellular tyrosinase activity. These results indicate that the observed decrease in melanin content after treatment with dehydroevodiamine was attributed to the direct inhibition of tyrosinase activity, rather than the suppression of tyrosinase gene expression. Dehydroevodiamine may be a promising new agent for use in cosmeceutical application.
Keyword
MelanogenesisEvodia rutaecarpaDehydroevodiamineSkin WhiteningCosmeceutical
ISSN
I000-0127
Publisher
Korea Soc-Assoc-Inst
DOI
http://dx.doi.org/10.1007/s11814-010-0147-1
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Microbial Biotechnology Research Center > 1. Journal Articles
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