Synthesis and In vitro cytotoxic activities of 2-Alkyl-2,3-dihydro-1H-2,6-diazacyclopenta(b)anthracene-5,10-diones

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Title
Synthesis and In vitro cytotoxic activities of 2-Alkyl-2,3-dihydro-1H-2,6-diazacyclopenta(b)anthracene-5,10-diones
Author(s)
J H Kwak; K Namgoong; J K Jung; S B Han; J Cho; Hwan Mook Kim; Song Kyu Park; Kiho Lee; Jong Soon Kang; H Lee
Bibliographic Citation
Archives of Pharmacal Research, vol. 33, no. 5, pp. 663-667
Publication Year
2010
Abstract
A series of 2-alkyl-2,3-dihydro-1H-2,6-diazacyclopenta[b]anthracene-5,10- diones (4a-f) was synthesized and their in vitro cytotoxic activities were evaluated against six human cancer cell lines (HCT15, SK-OV-3, SNB19, A549, MCF7 and MCF7/ADR). They all appeared to be less potent than doxorubicin against all doxorubicin sensitive human cancer cell lines tested. However, these compounds retained considerable cytotoxic activity against the doxorubicin-resistant cell line MCF7/ADR, implying their therapeutic potential to treat doxorubicin-resistant tumors. The most active compound 4c was equipotent with doxorubicin against HCT15 cell line.
Keyword
Cytotoxic activityDiazacyclopenta[b]anthracene-5,10-diones
ISSN
0253-6269
Publisher
Pharmaceutical Soc Korea
DOI
http://dx.doi.org/10.1007/s12272-010-0503-z
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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