New prenylated flavanones from erythrina abyssinica with protein tyrosine phosphatase 1B (PTP1B) inhibitory activity

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Title
New prenylated flavanones from erythrina abyssinica with protein tyrosine phosphatase 1B (PTP1B) inhibitory activity
Author(s)
L Cui; Hyun Sun Lee; D T Ndinteh; J T Mbafor; Y H Kim; T V T Le; P H Nguyen; W K Oh
Bibliographic Citation
Planta Medica, vol. 76, no. 7, pp. 713-718
Publication Year
2010
Abstract
As the insulin and leptin signaling pathway can be regulated by PTP1B, it has been suggested that compounds that reduce PTP1B activity or expression levels can be used for treating type 2 diabetes and obesity. In the course of our screening efforts on new PTP1B inhibitors, six new flavanones (16) with dihydrofuran moiety and two known flavanones (7 and 8) were isolated from the stem bark of Erythrina abyssinica (Leguminosae). Their structures were elucidated on the basis of spectroscopic (including UV, CD, MS, 1D, and 2DNMR) and physicochemical analyses. With the exception of 3 and 5, the compounds inhibited PTP1B activity in an in vitro assay with IC50 values ranging from 15.2±1.2 to 19.6±2.3μM, whereas RK-682 as a positive control displayed an IC50 value of 4.7±0.5μM.
Keyword
DiabetesDihydrofuranoflavanonesErythrina abyssinicaLeguminosaeProtein tyrosine phosphatase 1B
ISSN
0032-0943
Publisher
Georg Thieme Verlag Kg
DOI
http://dx.doi.org/10.1055/s-0029-1240682
Type
Article
Appears in Collections:
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
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