Ellagic acid protects hepatocytes from damage by inhibiting mitochondrial production of reactive oxygen species

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dc.contributor.authorJ M Hwang-
dc.contributor.authorJ S Cho-
dc.contributor.authorT H Kim-
dc.contributor.authorYoung Ik Lee-
dc.date.accessioned2017-04-19T09:18:42Z-
dc.date.available2017-04-19T09:18:42Z-
dc.date.issued2010-
dc.identifier.issn0753-3322-
dc.identifier.uri10.1016/j.biopha.2009.06.013ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9547-
dc.description.abstractThe aim of this experiment is to investigate the antioxidative and antiapoptotic roles of ellagic (EA) acid in in vitro and in in vivo experiment. We measured protective properties of EA against oxidative stress-induced hepatocyte damage in vitro and Concanavalin (ConA)-induced liver damage in vivo. EA, a potent antioxidant, exhibited protective properties against oxidative stress-induced hepatocyte damage by preventing vitamin k3 (VK3)-induced reactive oxygen species (ROS) productions, apoptotic and necrotic cellular damage and mitochondrial depolarization, which is a main cause of ROS production. EA also protects against cell death and elevation of glutathione (GSH), alanine transaminase (ALT) and asparatate transaminase (AST) in Con A-induced fulminant liver damage in mice. These results show that antioxidant and cytoprotective properties of EA prevent liver damage induced by various type of oxidative stress.-
dc.publisherElsevier-
dc.titleEllagic acid protects hepatocytes from damage by inhibiting mitochondrial production of reactive oxygen species-
dc.title.alternativeEllagic acid protects hepatocytes from damage by inhibiting mitochondrial production of reactive oxygen species-
dc.typeArticle-
dc.citation.titleBiomedicine & Pharmacotherapy-
dc.citation.number4-
dc.citation.endPage270-
dc.citation.startPage264-
dc.citation.volume64-
dc.contributor.affiliatedAuthorYoung Ik Lee-
dc.contributor.alternativeName황정미-
dc.contributor.alternativeName조진숙-
dc.contributor.alternativeName김태현-
dc.contributor.alternativeName이영익-
dc.identifier.bibliographicCitationBiomedicine & Pharmacotherapy, vol. 64, no. 4, pp. 264-270-
dc.identifier.doi10.1016/j.biopha.2009.06.013-
dc.subject.keywordApoptosis-
dc.subject.keywordConcanavalin A-
dc.subject.keywordCytoprotective effect-
dc.subject.keywordEllagic acid-
dc.subject.keywordMitochondrial depolarization-
dc.subject.keywordReactive oxygen species-
dc.subject.localapoptosis-
dc.subject.localApoptosis-
dc.subject.localConcanavalin A.-
dc.subject.localconcanavalin A-
dc.subject.localConcanavalin A-
dc.subject.localCytoprotective effect-
dc.subject.localEllagic acid-
dc.subject.localellagic acid-
dc.subject.localMitochondrial depolarization-
dc.subject.localmitochondrial depolarization-
dc.subject.localReactive oxidative species-
dc.subject.localReactive oxygen species(ROS)-
dc.subject.localReactive oxygen species-
dc.subject.localReactive Oxygen Species (ROS)-
dc.subject.localReactive Oxygen Species-
dc.subject.localROS-
dc.subject.localReactive oxygen species (ROS)-
dc.subject.localreactive oxygen species-
dc.subject.localreactive oxygen species (ROS)-
dc.description.journalClassY-
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