DC Field | Value | Language |
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dc.contributor.author | J M Hwang | - |
dc.contributor.author | J S Cho | - |
dc.contributor.author | T H Kim | - |
dc.contributor.author | Young Ik Lee | - |
dc.date.accessioned | 2017-04-19T09:18:42Z | - |
dc.date.available | 2017-04-19T09:18:42Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0753-3322 | - |
dc.identifier.uri | 10.1016/j.biopha.2009.06.013 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/9547 | - |
dc.description.abstract | The aim of this experiment is to investigate the antioxidative and antiapoptotic roles of ellagic (EA) acid in in vitro and in in vivo experiment. We measured protective properties of EA against oxidative stress-induced hepatocyte damage in vitro and Concanavalin (ConA)-induced liver damage in vivo. EA, a potent antioxidant, exhibited protective properties against oxidative stress-induced hepatocyte damage by preventing vitamin k3 (VK3)-induced reactive oxygen species (ROS) productions, apoptotic and necrotic cellular damage and mitochondrial depolarization, which is a main cause of ROS production. EA also protects against cell death and elevation of glutathione (GSH), alanine transaminase (ALT) and asparatate transaminase (AST) in Con A-induced fulminant liver damage in mice. These results show that antioxidant and cytoprotective properties of EA prevent liver damage induced by various type of oxidative stress. | - |
dc.publisher | Elsevier | - |
dc.title | Ellagic acid protects hepatocytes from damage by inhibiting mitochondrial production of reactive oxygen species | - |
dc.title.alternative | Ellagic acid protects hepatocytes from damage by inhibiting mitochondrial production of reactive oxygen species | - |
dc.type | Article | - |
dc.citation.title | Biomedicine & Pharmacotherapy | - |
dc.citation.number | 4 | - |
dc.citation.endPage | 270 | - |
dc.citation.startPage | 264 | - |
dc.citation.volume | 64 | - |
dc.contributor.affiliatedAuthor | Young Ik Lee | - |
dc.contributor.alternativeName | 황정미 | - |
dc.contributor.alternativeName | 조진숙 | - |
dc.contributor.alternativeName | 김태현 | - |
dc.contributor.alternativeName | 이영익 | - |
dc.identifier.bibliographicCitation | Biomedicine & Pharmacotherapy, vol. 64, no. 4, pp. 264-270 | - |
dc.identifier.doi | 10.1016/j.biopha.2009.06.013 | - |
dc.subject.keyword | Apoptosis | - |
dc.subject.keyword | Concanavalin A | - |
dc.subject.keyword | Cytoprotective effect | - |
dc.subject.keyword | Ellagic acid | - |
dc.subject.keyword | Mitochondrial depolarization | - |
dc.subject.keyword | Reactive oxygen species | - |
dc.subject.local | apoptosis | - |
dc.subject.local | Apoptosis | - |
dc.subject.local | Concanavalin A. | - |
dc.subject.local | concanavalin A | - |
dc.subject.local | Concanavalin A | - |
dc.subject.local | Cytoprotective effect | - |
dc.subject.local | Ellagic acid | - |
dc.subject.local | ellagic acid | - |
dc.subject.local | Mitochondrial depolarization | - |
dc.subject.local | mitochondrial depolarization | - |
dc.subject.local | Reactive oxidative species | - |
dc.subject.local | Reactive oxygen species(ROS) | - |
dc.subject.local | Reactive oxygen species | - |
dc.subject.local | Reactive Oxygen Species (ROS) | - |
dc.subject.local | Reactive Oxygen Species | - |
dc.subject.local | ROS | - |
dc.subject.local | Reactive oxygen species (ROS) | - |
dc.subject.local | reactive oxygen species | - |
dc.subject.local | reactive oxygen species (ROS) | - |
dc.description.journalClass | Y | - |
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