A highly sensitive enzyme-amplified immunosensor based on a nanoporous niobium oxide (Nb2O5) electrode = 다공성 니오븀산화물 전극을 이용한 고감도 효소증폭 면역센서

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dc.contributor.authorChang-Soo Lee-
dc.contributor.authorDohyoung Kwon-
dc.contributor.authorJ E Yoo-
dc.contributor.authorB G Lee-
dc.contributor.authorJ Choi-
dc.contributor.authorBong Hyun Chung-
dc.date.accessioned2017-04-19T09:18:45Z-
dc.date.available2017-04-19T09:18:45Z-
dc.date.issued2010-
dc.identifier.issn1424-8220-
dc.identifier.uri10.3390/s100505160ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9549-
dc.description.abstractWe report on the development of an enzyme-amplified sandwich-type immunosensor based on a thin gold film sputtered on an anodic nanoporous niobium oxide (Au@Nb2O5) electrode. The electrocatalytic activity of enzymatically amplified electroactive species and a stable electrode consisting of Au@Nb2O5 were used to obtain a powerful signal amplification of the electrochemical immunobiosensor. The method using this electrochemical biosensor based on an Au@Nb2O5 electrode provides a much better performance than those based on conventional bulk gold or niobium oxide electrodes. Our novel approach does not require any time-consuming cleaning steps to yield reproducible electrochemical signals. In addition, the strong adhesion of gold films on the niobium oxide electrodes offers a very stable substrate during electrochemical biosensing. Cyclic voltammetry measurements indicate that non-specific binding of proteins to the modified Au@Nb2O5 surface is sufficiently low to be ignored in the case of our novel system. Finally, we demonstrated the ability of the biosensor based on an Au@Nb2O5 offering the enhanced performance with a high resolution and sensitivity. Therefore, it is expected that the biosensor based on an Au@Nb2O5 has great potential for highly efficient biological devices.-
dc.publisherMDPI-
dc.titleA highly sensitive enzyme-amplified immunosensor based on a nanoporous niobium oxide (Nb2O5) electrode = 다공성 니오븀산화물 전극을 이용한 고감도 효소증폭 면역센서-
dc.title.alternativeA highly sensitive enzyme-amplified immunosensor based on a nanoporous niobium oxide (Nb2O5) electrode-
dc.typeArticle-
dc.citation.titleSensors-
dc.citation.number5-
dc.citation.endPage5170-
dc.citation.startPage5160-
dc.citation.volume10-
dc.contributor.affiliatedAuthorChang-Soo Lee-
dc.contributor.affiliatedAuthorDohyoung Kwon-
dc.contributor.affiliatedAuthorBong Hyun Chung-
dc.contributor.alternativeName이창수-
dc.contributor.alternativeName권도형-
dc.contributor.alternativeName유정은-
dc.contributor.alternativeName이병근-
dc.contributor.alternativeName최진섭-
dc.contributor.alternativeName정봉현-
dc.identifier.bibliographicCitationSensors, vol. 10, no. 5, pp. 5160-5170-
dc.identifier.doi10.3390/s100505160-
dc.subject.keywordElectrochemical biosensor-
dc.subject.keywordEnzyme-
dc.subject.keywordImmunosensor-
dc.subject.keywordNiobium oxide-
dc.subject.localElectrochemical biosensors-
dc.subject.localElectrochemical biosensor-
dc.subject.localenzyme-
dc.subject.localEnzymes-
dc.subject.localEnzyme-
dc.subject.localenzymes-
dc.subject.localImmunosensor-
dc.subject.localNiobium oxide-
dc.description.journalClassY-
Appears in Collections:
Division of Research on National Challenges > Bionanotechnology Research Center > 1. Journal Articles
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