Synthesis of benzoxazole amides as novel antifungal agents against Malassezia furfur

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Title
Synthesis of benzoxazole amides as novel antifungal agents against Malassezia furfur
Author(s)
B J Kim; J Kim; Young Kook Kim; S Y Choi; H Y Park Choo
Bibliographic Citation
Bulletin of Korean Chemical Society, vol. 31, no. 5, pp. 1270-1274
Publication Year
2010
Abstract
Malassezia is a pathogenic fungus that causes skin diseases, such as tinea versicolor, atopic dermatitis and fatal sepsis. We report the synthesis of a series of benzoxazole amides and evaluation of their antifungal activity against Malassezia furfur. Twelve benzoxazole amides were prepared through the cyclization of the substituted 2-hydroxy aniline with N-(bis- methylsulfanylmethylene) amides. Among the prepared compounds, the compounds 4a, 8b, 8c and 8d showed in vitro antifungal activity.
Keyword
AntifungalBenzoxazole amidesMalassezia furfur
ISSN
0253-2964
Publisher
Wiley
DOI
http://dx.doi.org/10.5012/bkcs.2010.31.5.1270
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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