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- Title
- Synthesis of benzoxazole amides as novel antifungal agents against Malassezia furfur
- Author(s)
- B J Kim; J Kim; Young Kook Kim; S Y Choi; H Y Park Choo
- Bibliographic Citation
- Bulletin of Korean Chemical Society, vol. 31, no. 5, pp. 1270-1274
- Publication Year
- 2010
- Abstract
- Malassezia is a pathogenic fungus that causes skin diseases, such as tinea versicolor, atopic dermatitis and fatal sepsis. We report the synthesis of a series of benzoxazole amides and evaluation of their antifungal activity against Malassezia furfur. Twelve benzoxazole amides were prepared through the cyclization of the substituted 2-hydroxy aniline with N-(bis- methylsulfanylmethylene) amides. Among the prepared compounds, the compounds 4a, 8b, 8c and 8d showed in vitro antifungal activity.
- Keyword
- AntifungalBenzoxazole amidesMalassezia furfur
- ISSN
- 0253-2964
- Publisher
- Wiley
- DOI
- http://dx.doi.org/10.5012/bkcs.2010.31.5.1270
- Type
- Article
- Appears in Collections:
- 1. Journal Articles > Journal Articles
- Files in This Item:
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