Hypopigmentary action of dihydropyranocoumarin D2, a decursin derivative, as a MITF-degrading agent

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Title
Hypopigmentary action of dihydropyranocoumarin D2, a decursin derivative, as a MITF-degrading agent
Author(s)
D S Kim; S H Park; H K Lee; Soo-Jin Choo; J H Lee; G Y Song; Ick Dong Yoo; S B Kwon; J I Na; K C Park
Bibliographic Citation
Journal of Natural Products, vol. 73, no. 5, pp. 797-800
Publication Year
2010
Abstract
In this study, the decursin derivative dihydropyranocoumarin D2 (1) was selected for its effects on melanogenesis using a spontaneously immortalized mouse melanocyte cell line (Mel-Ab). The results showed that 1 effectively inhibited melanin synthesis in a concentration-dependent manner, but that it did not inhibit tyrosinase in a cell-free system. In addition, the changes in ERK, Akt, and microphthalmia-associated transcription factor (MITF) in response to treatment with 1 were assessed. The results revealed that ERK was dramatically up-regulated and MITF was down-regulated in response to treatment with 1, but that Akt was unchanged. Therefore, the effects of 1 on melanogenesis were examined in the absence or presence of PD98059 (a specific inhibitor of the ERK pathway). PD98059 restored hypopigmentation and the down-regulation of MITF induced by 1. Finally, MITF down-regulation by 1 was clearly restored by both chloroquine, a lysosomal proteolysis inhibitor, and MG132, a proteasome inhibitor.
ISSN
0163-3864
Publisher
Amer Chem Soc
DOI
http://dx.doi.org/10.1021/np900455j
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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