DC Field | Value | Language |
---|---|---|
dc.contributor.author | S Lee | - |
dc.contributor.author | H Choi | - |
dc.contributor.author | E Kim | - |
dc.contributor.author | H Kim | - |
dc.contributor.author | Young-Ho Park | - |
dc.contributor.author | Dae Yeul Yu | - |
dc.contributor.author | S J Yoon | - |
dc.contributor.author | J Kim | - |
dc.contributor.author | Y Sheen | - |
dc.contributor.author | S N Park | - |
dc.contributor.author | D Y Yoon | - |
dc.date.accessioned | 2017-04-19T09:18:52Z | - |
dc.date.available | 2017-04-19T09:18:52Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 1019-6439 | - |
dc.identifier.uri | 10.3892/ijo-00000670 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/9578 | - |
dc.description.abstract | In previous research, we focused on the discovery of K-ras biomarkers, and effects of genotoxic carcinogens on their expression were investigated in this study. It is well-known that mutated K-ras gene is involved in ∼30% of human cancers such as lung cancer. To search for K-ras oncogene-induced modulators in lung tissues of K-ras transgenic mice, we analyzed K-ras-specific genes and proteins related to cancer development, signal transduction, inflammation as well as tumor suppression in a previous study. In this study, we investigated the modulating effects of genotoxic carcinogen treatment on expression of K-ras-dependent modulated genes and proteins in lung tissues of K-ras Tg mice. In order to evaluate candidate K-ras markers modulated by genotoxic stress and to investigate whether a genotoxic carcinogen would enhance or inhibit carcinogenesis in lung tissues of the K-ras Tg mice, the anti-cancer drug melphalan was intraperitoneally injected into K-ras Tg mice every two days for four weeks. RT-qPCR and proteomics analyses were performed in order to confirm whether K-ras-specific biomarkers would be modulated by melphalan treatment in K-ras Tg mice. The decreased adenomas were histopathologically observed and K-ras expression was suppressed in melphalan-treated K-ras Tg mice. Melphalan also recovered the expression of K-ras-dependent modulated biomarkers. These results suggest that melphalan inhibits carcinogenesis via modulating K-ras-specific genes and proteins expressed in the lung tissues of K-ras Tg mice. | - |
dc.publisher | Spandidos Publ Ltd | - |
dc.title | Melphalan inhibits adenoma development through modulating the expression of K-ras-specific markers in K-ras Tg mice | - |
dc.title.alternative | Melphalan inhibits adenoma development through modulating the expression of K-ras-specific markers in K-ras Tg mice | - |
dc.type | Article | - |
dc.citation.title | International Journal of Oncology | - |
dc.citation.number | 1 | - |
dc.citation.endPage | 228 | - |
dc.citation.startPage | 219 | - |
dc.citation.volume | 37 | - |
dc.contributor.affiliatedAuthor | Young-Ho Park | - |
dc.contributor.affiliatedAuthor | Dae Yeul Yu | - |
dc.contributor.alternativeName | 이소정 | - |
dc.contributor.alternativeName | 최희숙 | - |
dc.contributor.alternativeName | 김은진 | - |
dc.contributor.alternativeName | 김희종 | - |
dc.contributor.alternativeName | 박영호 | - |
dc.contributor.alternativeName | 유대열 | - |
dc.contributor.alternativeName | 윤석주 | - |
dc.contributor.alternativeName | 김진만 | - |
dc.contributor.alternativeName | 신윤형 | - |
dc.contributor.alternativeName | 박순희 | - |
dc.contributor.alternativeName | 윤도영 | - |
dc.identifier.bibliographicCitation | International Journal of Oncology, vol. 37, no. 1, pp. 219-228 | - |
dc.identifier.doi | 10.3892/ijo-00000670 | - |
dc.subject.keyword | Cancer | - |
dc.subject.keyword | K-ras oncogene | - |
dc.subject.keyword | Melphalan | - |
dc.subject.keyword | Proteomics | - |
dc.subject.keyword | Tg mouse | - |
dc.subject.local | Cancers | - |
dc.subject.local | cancer | - |
dc.subject.local | Cancer | - |
dc.subject.local | K-ras oncogene | - |
dc.subject.local | Melphalan | - |
dc.subject.local | Proteomic | - |
dc.subject.local | Proteomics | - |
dc.subject.local | Tg mouse | - |
dc.description.journalClass | Y | - |
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