Melphalan inhibits adenoma development through modulating the expression of K-ras-specific markers in K-ras Tg mice

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dc.contributor.authorS Lee-
dc.contributor.authorH Choi-
dc.contributor.authorE Kim-
dc.contributor.authorH Kim-
dc.contributor.authorYoung-Ho Park-
dc.contributor.authorDae Yeul Yu-
dc.contributor.authorS J Yoon-
dc.contributor.authorJ Kim-
dc.contributor.authorY Sheen-
dc.contributor.authorS N Park-
dc.contributor.authorD Y Yoon-
dc.date.accessioned2017-04-19T09:18:52Z-
dc.date.available2017-04-19T09:18:52Z-
dc.date.issued2010-
dc.identifier.issn10196439-
dc.identifier.uri10.3892/ijo-00000670ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9578-
dc.description.abstractIn previous research, we focused on the discovery of K-ras biomarkers, and effects of genotoxic carcinogens on their expression were investigated in this study. It is well-known that mutated K-ras gene is involved in ∼30% of human cancers such as lung cancer. To search for K-ras oncogene-induced modulators in lung tissues of K-ras transgenic mice, we analyzed K-ras-specific genes and proteins related to cancer development, signal transduction, inflammation as well as tumor suppression in a previous study. In this study, we investigated the modulating effects of genotoxic carcinogen treatment on expression of K-ras-dependent modulated genes and proteins in lung tissues of K-ras Tg mice. In order to evaluate candidate K-ras markers modulated by genotoxic stress and to investigate whether a genotoxic carcinogen would enhance or inhibit carcinogenesis in lung tissues of the K-ras Tg mice, the anti-cancer drug melphalan was intraperitoneally injected into K-ras Tg mice every two days for four weeks. RT-qPCR and proteomics analyses were performed in order to confirm whether K-ras-specific biomarkers would be modulated by melphalan treatment in K-ras Tg mice. The decreased adenomas were histopathologically observed and K-ras expression was suppressed in melphalan-treated K-ras Tg mice. Melphalan also recovered the expression of K-ras-dependent modulated biomarkers. These results suggest that melphalan inhibits carcinogenesis via modulating K-ras-specific genes and proteins expressed in the lung tissues of K-ras Tg mice.-
dc.publisherSpandidos Publ Ltd-
dc.titleMelphalan inhibits adenoma development through modulating the expression of K-ras-specific markers in K-ras Tg mice-
dc.title.alternativeMelphalan inhibits adenoma development through modulating the expression of K-ras-specific markers in K-ras Tg mice-
dc.typeArticle-
dc.citation.titleInternational Journal of Oncology-
dc.citation.number1-
dc.citation.endPage228-
dc.citation.startPage219-
dc.citation.volume37-
dc.contributor.affiliatedAuthorYoung-Ho Park-
dc.contributor.alternativeName이소정-
dc.contributor.alternativeName최희숙-
dc.contributor.alternativeName김은진-
dc.contributor.alternativeName김희종-
dc.contributor.alternativeName박영호-
dc.contributor.alternativeName유대열-
dc.contributor.alternativeName윤석주-
dc.contributor.alternativeName김진만-
dc.contributor.alternativeName신윤형-
dc.contributor.alternativeName박순희-
dc.contributor.alternativeName윤도영-
dc.identifier.bibliographicCitationInternational Journal of Oncology, vol. 37, no. 1, pp. 219-228-
dc.identifier.doi10.3892/ijo-00000670-
dc.subject.keywordCancer-
dc.subject.keywordK-ras oncogene-
dc.subject.keywordMelphalan-
dc.subject.keywordProteomics-
dc.subject.keywordTg mouse-
dc.subject.localCancer-
dc.subject.localK-ras oncogene-
dc.subject.localMelphalan-
dc.subject.localProteomics-
dc.subject.localProteomic-
dc.subject.localTg mouse-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > Futuristic Animal Resource & Research Center > 1. Journal Articles
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