DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sohyun Yun | - |
dc.contributor.author | Suk Hyung Lee | - |
dc.contributor.author | Yun Hee Kang | - |
dc.contributor.author | Mi-Ra Jeong | - |
dc.contributor.author | Mi Jeong Kim | - |
dc.contributor.author | Mi-Sun Kim | - |
dc.contributor.author | piaozhenghao | - |
dc.contributor.author | Hyun-Woo Suh | - |
dc.contributor.author | Tae-Don Kim | - |
dc.contributor.author | P K Myung | - |
dc.contributor.author | Suk Ran Yoon | - |
dc.contributor.author | In Pyo Choi | - |
dc.date.accessioned | 2017-04-19T09:18:52Z | - |
dc.date.available | 2017-04-19T09:18:52Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 1567-5769 | - |
dc.identifier.uri | 10.1016/j.intimp.2010.01.009 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/9580 | - |
dc.description.abstract | NK cells play crucial roles in innate immunity and adaptive immunity. The detailed mechanisms, however, governing NK cell development remains unclear. In this study, we report that YC-1 significantly enhances NK cell populations differentiated from human umbilical cord blood hematopoietic stem cells (HSCs). NK cells increased by YC-1 display both phenotypic and functional features of fully mature NK (mNK) cells, but YC-1 does not affect the activation of mNK cells. YC-1 did not affect cGMP production and phosphorylation of STAT-5 which is essential for IL-15R signaling. On the other hand, YC-1 increased p38 MAPK phosphorylation during NK cell differentiation. Furthermore, p38 inhibitor SB203580 inhibited the differentiation of NK cells enhanced by YC-1. Taken together, these data suggest that YC-1 enhances NK cell differentiation through the activation of p38 MAPK which is involved in NK cell differentiation. | - |
dc.publisher | Elsevier | - |
dc.title | YC-1 enhances natural killer cell differentiation from hematopoietic stem cells | - |
dc.title.alternative | YC-1 enhances natural killer cell differentiation from hematopoietic stem cells | - |
dc.type | Article | - |
dc.citation.title | International Immunopharmacology | - |
dc.citation.number | 4 | - |
dc.citation.endPage | 486 | - |
dc.citation.startPage | 481 | - |
dc.citation.volume | 10 | - |
dc.contributor.affiliatedAuthor | Sohyun Yun | - |
dc.contributor.affiliatedAuthor | Suk Hyung Lee | - |
dc.contributor.affiliatedAuthor | Yun Hee Kang | - |
dc.contributor.affiliatedAuthor | Mi Jeong Kim | - |
dc.contributor.affiliatedAuthor | Mi-Sun Kim | - |
dc.contributor.affiliatedAuthor | piaozhenghao | - |
dc.contributor.affiliatedAuthor | Hyun-Woo Suh | - |
dc.contributor.affiliatedAuthor | Tae-Don Kim | - |
dc.contributor.affiliatedAuthor | Suk Ran Yoon | - |
dc.contributor.affiliatedAuthor | In Pyo Choi | - |
dc.contributor.alternativeName | 윤소현 | - |
dc.contributor.alternativeName | 이석형 | - |
dc.contributor.alternativeName | 강윤희 | - |
dc.contributor.alternativeName | 정미라 | - |
dc.contributor.alternativeName | 김미정 | - |
dc.contributor.alternativeName | 김미선 | - |
dc.contributor.alternativeName | 박정호 | - |
dc.contributor.alternativeName | 서현우 | - |
dc.contributor.alternativeName | 김태돈 | - |
dc.contributor.alternativeName | 명평근 | - |
dc.contributor.alternativeName | 윤석란 | - |
dc.contributor.alternativeName | 최인표 | - |
dc.identifier.bibliographicCitation | International Immunopharmacology, vol. 10, no. 4, pp. 481-486 | - |
dc.identifier.doi | 10.1016/j.intimp.2010.01.009 | - |
dc.subject.keyword | Differentiation | - |
dc.subject.keyword | Hematopoietic stem cells | - |
dc.subject.keyword | NK cells | - |
dc.subject.keyword | p38 | - |
dc.subject.keyword | YC-1 | - |
dc.subject.local | Differentiation | - |
dc.subject.local | differentiation | - |
dc.subject.local | Hematopoietic stem cell | - |
dc.subject.local | Hematopoietic stem cells | - |
dc.subject.local | hematopoietic stem cell | - |
dc.subject.local | NK cell | - |
dc.subject.local | NK cells | - |
dc.subject.local | P38 | - |
dc.subject.local | p38 | - |
dc.subject.local | YC-1 | - |
dc.description.journalClass | Y | - |
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