YC-1 enhances natural killer cell differentiation from hematopoietic stem cells

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dc.contributor.authorSohyun Yun-
dc.contributor.authorSuk Hyung Lee-
dc.contributor.authorYun Hee Kang-
dc.contributor.authorMi-Ra Jeong-
dc.contributor.authorMi Jeong Kim-
dc.contributor.authorMi-Sun Kim-
dc.contributor.authorpiaozhenghao-
dc.contributor.authorHyun-Woo Suh-
dc.contributor.authorTae-Don Kim-
dc.contributor.authorP K Myung-
dc.contributor.authorSuk Ran Yoon-
dc.contributor.authorIn Pyo Choi-
dc.date.accessioned2017-04-19T09:18:52Z-
dc.date.available2017-04-19T09:18:52Z-
dc.date.issued2010-
dc.identifier.issn1567-5769-
dc.identifier.uri10.1016/j.intimp.2010.01.009ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9580-
dc.description.abstractNK cells play crucial roles in innate immunity and adaptive immunity. The detailed mechanisms, however, governing NK cell development remains unclear. In this study, we report that YC-1 significantly enhances NK cell populations differentiated from human umbilical cord blood hematopoietic stem cells (HSCs). NK cells increased by YC-1 display both phenotypic and functional features of fully mature NK (mNK) cells, but YC-1 does not affect the activation of mNK cells. YC-1 did not affect cGMP production and phosphorylation of STAT-5 which is essential for IL-15R signaling. On the other hand, YC-1 increased p38 MAPK phosphorylation during NK cell differentiation. Furthermore, p38 inhibitor SB203580 inhibited the differentiation of NK cells enhanced by YC-1. Taken together, these data suggest that YC-1 enhances NK cell differentiation through the activation of p38 MAPK which is involved in NK cell differentiation.-
dc.publisherElsevier-
dc.titleYC-1 enhances natural killer cell differentiation from hematopoietic stem cells-
dc.title.alternativeYC-1 enhances natural killer cell differentiation from hematopoietic stem cells-
dc.typeArticle-
dc.citation.titleInternational Immunopharmacology-
dc.citation.number4-
dc.citation.endPage486-
dc.citation.startPage481-
dc.citation.volume10-
dc.contributor.affiliatedAuthorSohyun Yun-
dc.contributor.affiliatedAuthorSuk Hyung Lee-
dc.contributor.affiliatedAuthorYun Hee Kang-
dc.contributor.affiliatedAuthorMi Jeong Kim-
dc.contributor.affiliatedAuthorMi-Sun Kim-
dc.contributor.affiliatedAuthorpiaozhenghao-
dc.contributor.affiliatedAuthorHyun-Woo Suh-
dc.contributor.affiliatedAuthorTae-Don Kim-
dc.contributor.affiliatedAuthorSuk Ran Yoon-
dc.contributor.affiliatedAuthorIn Pyo Choi-
dc.contributor.alternativeName윤소현-
dc.contributor.alternativeName이석형-
dc.contributor.alternativeName강윤희-
dc.contributor.alternativeName정미라-
dc.contributor.alternativeName김미정-
dc.contributor.alternativeName김미선-
dc.contributor.alternativeName박정호-
dc.contributor.alternativeName서현우-
dc.contributor.alternativeName김태돈-
dc.contributor.alternativeName명평근-
dc.contributor.alternativeName윤석란-
dc.contributor.alternativeName최인표-
dc.identifier.bibliographicCitationInternational Immunopharmacology, vol. 10, no. 4, pp. 481-486-
dc.identifier.doi10.1016/j.intimp.2010.01.009-
dc.subject.keywordDifferentiation-
dc.subject.keywordHematopoietic stem cells-
dc.subject.keywordNK cells-
dc.subject.keywordp38-
dc.subject.keywordYC-1-
dc.subject.localDifferentiation-
dc.subject.localdifferentiation-
dc.subject.localHematopoietic stem cell-
dc.subject.localHematopoietic stem cells-
dc.subject.localhematopoietic stem cell-
dc.subject.localNK cell-
dc.subject.localNK cells-
dc.subject.localP38-
dc.subject.localp38-
dc.subject.localYC-1-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
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