Puzzling inefficiency of H5N1 influenza vaccines in Egyptian poultry

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dc.contributor.authorJeong Ki Kim-
dc.contributor.authorG Kayali-
dc.contributor.authorD Walker-
dc.contributor.authorH L Forrest-
dc.contributor.authorA H Ellebedy-
dc.contributor.authorY S Griffin-
dc.contributor.authorA Rubrum-
dc.contributor.authorM M Bahgat-
dc.contributor.authorM A Kutkat-
dc.contributor.authorM A A Ali-
dc.contributor.authorJ R Aldridge-
dc.contributor.authorN J Negovetich-
dc.contributor.authorS Krauss-
dc.contributor.authorR J Webby-
dc.contributor.authorR G Webster-
dc.date.accessioned2017-04-19T09:18:52Z-
dc.date.available2017-04-19T09:18:52Z-
dc.date.issued2010-
dc.identifier.issn0027-8424-
dc.identifier.uri10.1073/pnas.1006419107ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9584-
dc.description.abstractIn Egypt, efforts to control highly pathogenic H5N1 avian influenza virus in poultry and in humans have failed despite increased biosecurity, quarantine, and vaccination at poultry farms. The ongoing circulation of HP H5N1 avian influenza in Egypt has caused >100 human infections and remains an unresolved threat to veterinary and public health. Here,we describe that the failure of commercially available H5 poultry vaccines in Egyptmay be caused in part by the passive transfer of maternal H5N1 antibodies to chicks, inhibiting their immune response to vaccination. We propose that the induction of a protective immune response to H5N1 is suppressed for an extended period in young chickens. This issue, among others,must be resolved and additional steps must be taken before the outbreaks in Egypt can be controlled.-
dc.publisherNatl Acad Sciences-
dc.titlePuzzling inefficiency of H5N1 influenza vaccines in Egyptian poultry-
dc.title.alternativePuzzling inefficiency of H5N1 influenza vaccines in Egyptian poultry-
dc.typeArticle-
dc.citation.titleProceedings of National Academy of Sciences of United States of America-
dc.citation.number24-
dc.citation.endPage11049-
dc.citation.startPage11044-
dc.citation.volume107-
dc.contributor.affiliatedAuthorJeong Ki Kim-
dc.contributor.alternativeName김정기-
dc.contributor.alternativeNameKayali-
dc.contributor.alternativeNameWalker-
dc.contributor.alternativeNameForrest-
dc.contributor.alternativeNameEllebedy-
dc.contributor.alternativeNameGriffin-
dc.contributor.alternativeNameRubrum-
dc.contributor.alternativeNameBahgat-
dc.contributor.alternativeNameKutkat-
dc.contributor.alternativeNameAli-
dc.contributor.alternativeNameAldridge-
dc.contributor.alternativeNameNegovetich-
dc.contributor.alternativeNameKrauss-
dc.contributor.alternativeNameWebby-
dc.contributor.alternativeNameWebster-
dc.identifier.bibliographicCitationProceedings of National Academy of Sciences of United States of America, vol. 107, no. 24, pp. 11044-11049-
dc.identifier.doi10.1073/pnas.1006419107-
dc.subject.keywordImmune-
dc.subject.keywordMaternally transferred antibodies-
dc.subject.keywordSuppression-
dc.subject.localimmune-
dc.subject.localImmune-
dc.subject.localMaternally transferred antibodies-
dc.subject.localSuppression-
dc.subject.localsuppression-
dc.description.journalClassY-
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