Newly identified tumor-associated role of human Sharpin

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dc.contributor.authorJ Jung-
dc.contributor.authorJ M Kim-
dc.contributor.authorB Park-
dc.contributor.authorY Cheon-
dc.contributor.authorB Lee-
dc.contributor.authorS H Choo-
dc.contributor.authorSang Seok Koh-
dc.contributor.authorS Lee-
dc.date.accessioned2017-04-19T09:19:01Z-
dc.date.available2017-04-19T09:19:01Z-
dc.date.issued2010-
dc.identifier.issn0300-8177-
dc.identifier.uri10.1007/s11010-010-0413-xko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9602-
dc.description.abstractIn order to discover previously unidentified cancer-associated genes, we analyzed genome-wide differences in gene expression between tumor biopsies and normal tissues. Among those differentially regulated genes, we identified Sharpin (Shank-associated RH domain-interacting protein) as a commonly up-regulated gene in multiple human cancer types. Although rat Sharpin is reported to interact with Shank1, a multidomain scaffold protein localized in postsynaptic densities, its exact roles are unknown. Whereas human Sharpin homologue was primarily localized in the cytosol of cultured cells, they were detected in both cytosol and nucleus of the cells from ovarian and liver cancer tissues using immunohistochemical staining. In addition, Chinese ovary hamster cells over-expressing Sharpin exhibited enhanced cancer-specific phenotypes in multiple in vitro tumor assays. Taken together, the results suggest that Sharpin is not an inert scaffold protein, but may play tumor-associated roles during cancer biogenesis.-
dc.publisherSpringer-
dc.titleNewly identified tumor-associated role of human Sharpin-
dc.title.alternativeNewly identified tumor-associated role of human Sharpin-
dc.typeArticle-
dc.citation.titleMolecular and Cellular Biochemistry-
dc.citation.number1-
dc.citation.endPage167-
dc.citation.startPage161-
dc.citation.volume340-
dc.contributor.affiliatedAuthorSang Seok Koh-
dc.contributor.alternativeName정진영-
dc.contributor.alternativeName김진만-
dc.contributor.alternativeName박병우-
dc.contributor.alternativeName전영미-
dc.contributor.alternativeName이복만-
dc.contributor.alternativeName추승호-
dc.contributor.alternativeName고상석-
dc.contributor.alternativeName이수진-
dc.identifier.bibliographicCitationMolecular and Cellular Biochemistry, vol. 340, no. 1, pp. 161-167-
dc.identifier.doi10.1007/s11010-010-0413-x-
dc.subject.keywordImmunohistochemistry-
dc.subject.keywordInvasion assay-
dc.subject.keywordOncogene-
dc.subject.keywordOncology database-
dc.subject.keywordPost-synaptic density-
dc.subject.keywordShank-associated RH domain-interacting protein-
dc.subject.localImmunohistochemistry-
dc.subject.localimmunohistochemistry-
dc.subject.localimmunohistochimistry-
dc.subject.localInvasion assay-
dc.subject.localinvasion assay-
dc.subject.localOncogene-
dc.subject.localoncogene-
dc.subject.localOncogenes-
dc.subject.localOncology database-
dc.subject.localPost-synaptic density-
dc.subject.localShank-associated RH domain-interacting protein-
dc.description.journalClassY-
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