Modulatory effect of four azulene derivatives from the fruiting bodies of Lactarius hatsudake on interferon-gamma production = 젖버섯아재비 자실체로부터 분리한 azulene계 화합물이 interferon-gamma 생성에 미치는 영향

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Title
Modulatory effect of four azulene derivatives from the fruiting bodies of Lactarius hatsudake on interferon-gamma production = 젖버섯아재비 자실체로부터 분리한 azulene계 화합물이 interferon-gamma 생성에 미치는 영향
Author(s)
G H Xu; Jae Wha Kim; G Li; Ick Dong Yoo
Bibliographic Citation
Journal of Society of Cosmetic Scientists of Korea, vol. 36, no. 2, pp. 151-156
Publication Year
2010
Abstract
Investigation of secondary bioactive metabolites from the fruiting bodies of Lactarius hatsudake led to the isolation of four azulene derivatives by means of repeated column chromatography and preparative HPLC, and they were identified as 1-formyl-4-methyl-7-isopropyl azulene (1), lactaroviolin (2), 4-methyl-7-isopropyl-azulene-1-carboxylic acid (3), and 1-formyl-4-methyl-7-(1-hydroxy-1-methylethyl) azulene (4) by their physico-chemical properties and spectroscopic analysis. The isolated compounds were evaluated for the effects on modulation of cytokines in natural killer cell line (NK92 cells). Compounds 1 and 4 strongly inhibited IFN-γ production in a dose-dependent manner, corresponding to 101.3 % and 92.7 % inhibition at 400 μM, and 11.9 % and 24.1 % at 100 μM, respectively, whereas compounds 2 and 3 showed weak inhibitory effect on INF-γ production, corresponding to 45.9% and 18.0 % inhibition at 400 μM.
Keyword
Lactarius hatsudakeazuleneinterferon-γnatural killer cell
ISSN
1226-2587
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
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