The Drosophila homolog of methionine sulfoxide reductase A extends lifespan and increases nuclear localization of FOXO

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dc.contributor.authorH CHung-
dc.contributor.authorAe Kyeong Kim-
dc.contributor.authorS A Jung-
dc.contributor.authorS W Kim-
dc.contributor.authorKweon Yu-
dc.contributor.authorJ H Lee-
dc.date.accessioned2017-04-19T09:19:28Z-
dc.date.available2017-04-19T09:19:28Z-
dc.date.issued2010-
dc.identifier.issn0014-5793-
dc.identifier.uri10.1016/j.febslet.2010.07.033ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9681-
dc.description.abstractMethionine sulfoxide reductase A (msrA) was previously found to increase resistance to oxidative stress and longevity in animals. We identified Drosophila msrA (dmsrA), a Drosophila homolog of human msrA, as a downstream effector of forkhead box O (FOXO) signaling in Drosophila, which enhances resistance to oxidative stress and increases survival under stressed conditions. Additionally, overexpression of dmsrA in neurons extended the lifespan of flies. Moreover, overexpression of dmsrA in fat body cells caused FOXO to translocate to the nucleus, implying that this possible positive feedback loop between dmsrA and FOXO could potentiate the antioxidant activity of dmsrA and increase the lifespan in Drosophila.-
dc.publisherWiley-
dc.titleThe Drosophila homolog of methionine sulfoxide reductase A extends lifespan and increases nuclear localization of FOXO-
dc.title.alternativeThe Drosophila homolog of methionine sulfoxide reductase A extends lifespan and increases nuclear localization of FOXO-
dc.typeArticle-
dc.citation.titleFEBS Letters-
dc.citation.number16-
dc.citation.endPage3614-
dc.citation.startPage3609-
dc.citation.volume584-
dc.contributor.affiliatedAuthorAe Kyeong Kim-
dc.contributor.affiliatedAuthorKweon Yu-
dc.contributor.alternativeName정혜원-
dc.contributor.alternativeName김애경-
dc.contributor.alternativeName정선아-
dc.contributor.alternativeName김시욱-
dc.contributor.alternativeName유권-
dc.contributor.alternativeName이준행-
dc.identifier.bibliographicCitationFEBS Letters, vol. 584, no. 16, pp. 3609-3614-
dc.identifier.doi10.1016/j.febslet.2010.07.033-
dc.subject.keywordAntioxidant enzyme-
dc.subject.keywordDrosophila-
dc.subject.keywordForkhead box O-
dc.subject.keywordLifespan-
dc.subject.keywordLongevity-
dc.subject.keywordMethionine sulfoxide reductase A-
dc.subject.keywordOxidative stress-
dc.subject.keywordTranscription-
dc.subject.keywordTranslocation-
dc.subject.localantioxidant enzyme-
dc.subject.localAntioxidant enzymes-
dc.subject.localantioxidant enzymes-
dc.subject.localAnti-oxidant enzyme-
dc.subject.localAntioxidant enzyme-
dc.subject.localAntioxidant Enzymes-
dc.subject.localdrosophila-
dc.subject.localDrosophila-
dc.subject.localForkhead box O-
dc.subject.locallifespan-
dc.subject.localLifespan-
dc.subject.locallongevity-
dc.subject.localLongevity-
dc.subject.localMethionine sulfoxide reductase A-
dc.subject.localOxidative stre-
dc.subject.localOxidative stress-
dc.subject.localOXIDATIVE STRESS-
dc.subject.localOxidative Stress-
dc.subject.localoxidative stress-
dc.subject.localTranscription-
dc.subject.localtranscription-
dc.subject.localTranslocation-
dc.subject.localtranslocation-
dc.description.journalClassY-
Appears in Collections:
Division of Research on National Challenges > Bionanotechnology Research Center > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > 1. Journal Articles
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