Production of recombinant human granulocyte macrophage colony-stimulating factor from silkworm Bombyx mori Bm5 cells

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Title
Production of recombinant human granulocyte macrophage colony-stimulating factor from silkworm Bombyx mori Bm5 cells
Author(s)
C Y Jin; S Y Han; K Kwon; E Y Yun; S W Kang; T W Goo; S W Kim; Kweon Yu; O Y Kwon
Bibliographic Citation
Zeitschrift fur Naturforschung Section C-A Journal of Biosciences, vol. 65, no. 1, pp. 153-156
Publication Year
2010
Abstract
Using silkworm Bombyx mori Bm5 cells, we established a stable cell line expressing the human granulocyte macrophage colony-stimulating factor (hGM-CSF), which gets its name from the Bm5-hGM-CSF cell in which the glycoprotein of the hGM-CSF is secreted in the cell culture supernatant (CCS). It was demonstrated that secreted hGM-CSF had in vivo biological activity and the white blood cell (WBC) value increased two times that of the control. We expect to produce useful human recombinant glycoproteins from silkworm cultured cells for a low price and a large quantity.
Keyword
Human granulocyte macrophage colony-stimulating factorSilkworm bombyx mori bm5 cellsWhite blood cell
ISSN
0939-5075
Publisher
Walter De Gruyter Gmbh
DOI
http://dx.doi.org/10.1515/znc-2010-1-224
Type
Article
Appears in Collections:
Division of Biomedical Research > Disease Target Structure Research Center > 1. Journal Articles
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