Network analysis of hepatic genes responded to high-fat diet in C57BL/6J Mice: Nutrigenomics data mining from recent research findings

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dc.contributor.authorE J Kim-
dc.contributor.authorE Kim-
dc.contributor.authorE Y Kwon-
dc.contributor.authorH S Jang-
dc.contributor.authorCheol-Goo Hur-
dc.contributor.authorM S Choi-
dc.date.accessioned2017-04-19T09:19:28Z-
dc.date.available2017-04-19T09:19:28Z-
dc.date.issued2010-
dc.identifier.issn1096620X-
dc.identifier.uri10.1089/jmf.2009.1350ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9684-
dc.description.abstractObesity and its associated complications, including diabetes, dyslipidemia, atherosclerosis, and some cancers, have been a global health problem with a rapid increase of the obese population. In this study, we selected 31 obesity candidate genes in the liver of high-fat-induced obese C57BL/6J mice through investigation of literature search and analyzed functional protein-protein interaction of the genes using the STRING database. Most of the obesity candidate genes were closely connected through lipid metabolism, and in particular acyl-coenzyme A oxidase 1 appeared to be a core obesity gene. Overall, genes involved in fatty acid β-oxidation, fatty acid synthesis, and gluconeogenesis were up-regulated, and genes involved in sterol biosynthesis, insulin signaling, and oxidative stress defense system were down-regulated with a high-fat diet. Future identification of core obesity genes and their functional targets is expected to provide a new way to prevent obesity by phytochemicals or functional foods on the basis of food and nutritional genomics.-
dc.publisherMary Ann Liebert, Inc-
dc.titleNetwork analysis of hepatic genes responded to high-fat diet in C57BL/6J Mice: Nutrigenomics data mining from recent research findings-
dc.title.alternativeNetwork analysis of hepatic genes responded to high-fat diet in C57BL/6J Mice: Nutrigenomics data mining from recent research findings-
dc.typeArticle-
dc.citation.titleJournal of Medicinal Food-
dc.citation.number4-
dc.citation.endPage756-
dc.citation.startPage743-
dc.citation.volume13-
dc.contributor.alternativeName김은정-
dc.contributor.alternativeName김은정-
dc.contributor.alternativeName권은영-
dc.contributor.alternativeName장현서-
dc.contributor.alternativeName허철구-
dc.contributor.alternativeName최명숙-
dc.identifier.bibliographicCitationJournal of Medicinal Food, vol. 13, no. 4, pp. 743-756-
dc.identifier.doi10.1089/jmf.2009.1350-
dc.subject.keywordhigh-fat diet-
dc.subject.keywordnutrigenomics-
dc.subject.keywordobesity-
dc.subject.localhigh-fat diet-
dc.subject.localHigh-fat diet-
dc.subject.localnutrigenomics-
dc.subject.localobesity-
dc.subject.localObesity-
dc.description.journalClassY-
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