Feasibility of FAIR imaging for evaluating tumor perfusion

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dc.contributor.authorJ H Cho-
dc.contributor.authorG Cho-
dc.contributor.authorY Song-
dc.contributor.authorC Lee-
dc.contributor.authorB W Park-
dc.contributor.authorC K Lee-
dc.contributor.authorN Kim-
dc.contributor.authorS B Park-
dc.contributor.authorJong Soon Kang-
dc.contributor.authorM R Kang-
dc.contributor.authorHwan Mook Kim-
dc.contributor.authorY R Kim-
dc.contributor.authorK S Cho-
dc.contributor.authorJ K Kim-
dc.date.accessioned2017-04-19T09:19:30Z-
dc.date.available2017-04-19T09:19:30Z-
dc.date.issued2010-
dc.identifier.issn10531807-
dc.identifier.uri10.1002/jmri.22298ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9696-
dc.description.abstractPurpose: To evaluate the feasibility of flow-sensitive alternating inversion recovery (FAIR) for measuring blood flow in tumor models. Materials and Methods: In eight mice tumor models, FAIR and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) was performed. The reliability for measuring blood flow on FAIR was evaluated using the coefficient of variation of blood flow on psoas muscle. Three regions of interest (ROIs) were drawn in the peripheral, intermediate, and central portions within each tumor. The location of ROI was the same on FAIR and DCE-MR images. The correlation between the blood flow on FAIR and perfusion-related parameters on DCE-MRI was evaluated using the Pearson correlation coefficient. Results: The coefficient of variation for measuring blood flow was 9.8%. Blood flow on FAIR showed a strong correlation with Kep (r = 0.77), percent relative enhancement (r = 0.73), and percent enhancement ratio (r = 0.81). The mean values of blood flow (mL/100 g/min) (358 vs. 207), Kep (sec-1) (7.46 vs. 1.31), percent relative enhancement (179% vs. 134%), and percent enhancement ratio (42% vs. 26%) were greater in the peripheral portion than in the central portion (P < 0.01). Conclusion: As blood flow measurement on FAIR is reliable and closely related with that on DCE-MR, FAIR is feasible for measuring tumor blood flow.-
dc.publisherWiley-
dc.titleFeasibility of FAIR imaging for evaluating tumor perfusion-
dc.title.alternativeFeasibility of FAIR imaging for evaluating tumor perfusion-
dc.typeArticle-
dc.citation.titleJournal of Magnetic Resonance Imaging-
dc.citation.number3-
dc.citation.endPage744-
dc.citation.startPage738-
dc.citation.volume32-
dc.contributor.affiliatedAuthorJong Soon Kang-
dc.contributor.alternativeName조지현-
dc.contributor.alternativeName조경구-
dc.contributor.alternativeName송영규-
dc.contributor.alternativeName이철현-
dc.contributor.alternativeName박범우-
dc.contributor.alternativeName이창경-
dc.contributor.alternativeName김남국-
dc.contributor.alternativeName박성빈-
dc.contributor.alternativeName강종순-
dc.contributor.alternativeName강무림-
dc.contributor.alternativeName김환묵-
dc.contributor.alternativeName김영로-
dc.contributor.alternativeName조경식-
dc.contributor.alternativeName김정곤-
dc.identifier.bibliographicCitationJournal of Magnetic Resonance Imaging, vol. 32, no. 3, pp. 738-744-
dc.identifier.doi10.1002/jmri.22298-
dc.subject.keywordAngiogenesis-
dc.subject.keywordArterial spin labeling-
dc.subject.keywordBlood flow-
dc.subject.keywordFlow-sensitive alternating inversion recovery-
dc.subject.keywordMagnetic resonance imaging-
dc.subject.localAngiogenesis-
dc.subject.localArterial spin labeling-
dc.subject.localBlood flow-
dc.subject.localFlow-sensitive alternating inversion recovery-
dc.subject.localMagnetic resonance imaging-
dc.subject.localMagnetic resonance imaging (MRI)-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > Laboratory Animal Resource Center > 1. Journal Articles
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