In vitro chemosensitivity of gastric adenocarcinomas to histone deacetylase inhibitors, compared to established drugs

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dc.contributor.authorS N Yoon-
dc.contributor.authorS A Roh-
dc.contributor.authorD H Cho-
dc.contributor.authorM B Kim-
dc.contributor.authorY L Hyun-
dc.contributor.authorS Ro-
dc.contributor.authorB S Kim-
dc.contributor.authorSeon-Young Kim-
dc.contributor.authorYong Sung Kim-
dc.contributor.authorJ C Kim-
dc.date.accessioned2017-04-19T09:19:31Z-
dc.date.available2017-04-19T09:19:31Z-
dc.date.issued2010-
dc.identifier.issn0172-6390-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9698-
dc.description.abstractBACKGROUND/AIMS: This study was performed to determine the efficacy of histone deacetylase inhibitors in gastric cancer, together with other established regimens. METHODOLOGY: The chemosensitivities of 93 gastric cancer patients to established drugs, and three histone deacetylase inhibitors (SAHA, PXD101, and a novel candidate, CG-2) were evaluated using the histoculture drug response assay. RESULTS: Tumor growth inhibition rates were the highest with cisplatin, followed by PXD101, taxol, docetaxel, and TS-1, in descending order. The response rates were 41.9-68.8%, and 37.6-47.3%, respectively, at an inhibition rate cutoff value of 30%. Synergistic activity was evident with most combinations of established drugs and histone deacetylase inhibitors. Diffuse- or mixed-type carcinomas on Lauren classification were closely associated with increased chemosensitivity to TS-1 (p = 0.044). Node-positive and "other than tubular type" tumors on WHO classification were chemosensitive to cisplatin (p = 0.011 and 0.014, respectively). CG-2 chemosensitivity was markedly associated with low preoperative CA72-4 level (≤4 U/ml) (p = 0.046). CONCLUSIONS: This in vitro chemosensitivity assay validates the comparable chemo-response of gastric cancers to histone deacetylase inhibitors and established drugs, indicating considerable therapeutic efficacy of these agents. Additionally, a number of clinicopathological parameters are significantly associated with specific regimens.-
dc.publisherHge Update Medical Publishing Sako
dc.titleIn vitro chemosensitivity of gastric adenocarcinomas to histone deacetylase inhibitors, compared to established drugs-
dc.title.alternativeIn vitro chemosensitivity of gastric adenocarcinomas to histone deacetylase inhibitors, compared to established drugs-
dc.typeArticle-
dc.citation.titleHepato-Gastroenterology-
dc.citation.number99-
dc.citation.endPage662-
dc.citation.startPage657-
dc.citation.volume57-
dc.contributor.affiliatedAuthorSeon-Young Kim-
dc.contributor.affiliatedAuthorYong Sung Kim-
dc.contributor.alternativeName윤상남-
dc.contributor.alternativeName노선애-
dc.contributor.alternativeName조동형-
dc.contributor.alternativeName김문보-
dc.contributor.alternativeName현영란-
dc.contributor.alternativeName노승구-
dc.contributor.alternativeName김병식-
dc.contributor.alternativeName김선영-
dc.contributor.alternativeName김용성-
dc.contributor.alternativeName김진천-
dc.identifier.bibliographicCitationHepato-Gastroenterology, vol. 57, no. 99, pp. 657-662-
dc.subject.keywordChemosensitivity-
dc.subject.keywordGastric adenocarcinomas-
dc.subject.keywordHistoculture drug response assay (HDRA)-
dc.subject.keywordHistone deacetylase inhibitor-
dc.subject.localChemosensitivity-
dc.subject.localchemosensitivity-
dc.subject.localGastric adenocarcinoma-
dc.subject.localGastric adenocarcinomas-
dc.subject.localHistoculture drug response assay-
dc.subject.localHistoculture drug response assay (HDRA)-
dc.subject.localHistone deacetylase inhibitor-
dc.subject.localhistone deacetylase inhibitor-
dc.description.journalClassN-
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