Xanthones with neuraminidase inhibitory activity from the seedcases of Garcinia mangostana = 망고스틴 씨껍질로부터 분리한 잔톤화합물의 뉴라미니데이즈 저해활성

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Title
Xanthones with neuraminidase inhibitory activity from the seedcases of Garcinia mangostana = 망고스틴 씨껍질로부터 분리한 잔톤화합물의 뉴라미니데이즈 저해활성
Author(s)
Hyung Won Ryu; M J Curtis-Long; S Jung; Y M Jin; J K Cho; Young Bae RyuWoo Song Lee; K H Park
Bibliographic Citation
Bioorganic & Medicinal Chemistry, vol. 18, pp. 6258-6264
Publication Year
2010
Abstract
This study was designed to gain deeper insights into the molecular properties of natural xanthones as neuraminidase inhibitors. A series of xanthones 1-12 was isolated from the seedcases of Garcinia mangostana and evaluated for bacteria neuraminidase inhibitory activity. Compounds 11 and 12 emerged to be new xanthones (mangostenone F, mangostenone G) which we fully spectroscopically characterized. The IC50 values of compounds 1-12 were determined to range between 0.27-65.7 μM. The most potent neuraminidase inhibitor 10 which has an IC50 of 270 nM features a 5,8-diol moiety on the B ring. Interestingly, structure-activity studies reveal that these xanthones show different kinetic inhibition mechanisms depending upon the arrangement of hydroxyl groups in the B ring. Compound 6 possessing a 6,7-diol motif on the B-ring operated under the enzyme isomerization model (k5 = 0.1144 μM-1 s-1, k6 = 0.001105 s -1, and Kiapp = 7.41 μM), whereas compound 10 possessing a 5,8-diol unit displayed simple reversible slow-binding inhibition (k3 = 0.02294 μM-1 s-1, k4 = 0.001025 s -1, and Kiapp = 0.04468 μM).
Keyword
Garcinia mangostanaNeuraminidaseTime-dependentXanthone
ISSN
0968-0896
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bmc.2010.07.033
Type
Article
Appears in Collections:
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
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