A new palm-sized surface plasmon resonance (SPR) biosensor based on modulation of a light source by a rotating mirror

Cited 48 time in scopus
Metadata Downloads
Title
A new palm-sized surface plasmon resonance (SPR) biosensor based on modulation of a light source by a rotating mirror
Author(s)
Yong Beom Shin; H M Kim; Yongwon Jung; Bong Hyun Chung
Bibliographic Citation
Sensors and Actuators B-Chemical, vol. 150, pp. 1-6
Publication Year
2010
Abstract
A novel surface plasmon resonance (SPR) sensing scheme was devised to develop a palm-sized SPR biosensor device. In this system, the beam from a diode laser (as the incident light source) is modulated using a rotating mirror. The reflected light from the gold chip is then captured using a CMOS image sensor, controlled by a notebook PC via a USB interface. This provides a portable POCT SPR sensor device which enables label-free and real-time analyses. This method can also eliminate the deterioration in image quality of the reflected laser light, originating from the coherency of the laser source. The sensing response of the system to the bulk refractive index was calibrated using various concentrations of glycerol solution. As a result, the SPR sensor was able to detect a ∼2.5 × 10-6 RIU change in the refractive index of the solution without implementing any of data processing techniques. The performance of the sensor was tested by monitoring the binding of PSA to its antibody in real-time to verify its potential applicability in analyzing biomolecular interactions. The results obtained from a series of tests confirmed the practicality of the sensor for the on-site detection of a variety of substances in biology, diagnosis, the environment, and defense
Keyword
BiosensorHandheldModulation by rotating mirrorSurface plasmon resonance (SPR)
ISSN
0925-4005
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.snb.2010.08.006
Type
Article
Appears in Collections:
Division of Biomaterials Research > Bionanotechnology Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.