Negative regulation of neuronal cell differentiation by INHAT subunit SET/TAF-Iβ

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Title
Negative regulation of neuronal cell differentiation by INHAT subunit SET/TAF-Iβ
Author(s)
D W Kim; K B Kim; J Y Kim; Kyu-Sun Lee; S B Seo
Bibliographic Citation
Biochemical and Biophysical Research Communications, vol. 400, no. 3, pp. 419-425
Publication Year
2010
Abstract
Epigenetic modification plays an important role in transcriptional regulation. As a subunit of the INHAT (inhibitor of histone acetyltransferases) complex, SET/TAF-Iβ evidences transcriptional repression activity. In this study, we demonstrate that SET/TAF-Iβ is abundantly expressed in neuronal tissues of Drosophila embryos. It is expressed at high levels prior to and in early stages of neuronal development, and gradually reduced as differentiation proceeds. SET/TAF-Iβ binds to the promoters of a subset of neuronal development markers and negatively regulates the transcription of these genes. The results of this study show that the knockdown of SET/TAF-Iβ by si-RNA induces neuronal cell differentiation, thus implicating SET/TAF-Iβ as a negative regulator of neuronal development.
Keyword
INHATNeuronal differentiationRetinoic acidSET/TAF-Iβ
ISSN
0006-291X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bbrc.2010.08.093
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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