Change in serum proteome during allogenic hematopoietic stem cell transplantation and clinical significance of serum C-reactive protein and haptoglobin

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dc.contributor.authorJoohyun Ryu-
dc.contributor.authorS R Lee-
dc.contributor.authorSung Goo Park-
dc.contributor.authorSunghyun Kang-
dc.contributor.authorH J Kim-
dc.contributor.authorByoung Chul Park-
dc.date.accessioned2017-04-19T09:19:44Z-
dc.date.available2017-04-19T09:19:44Z-
dc.date.issued2010-
dc.identifier.issnI000-0028-
dc.identifier.uri10.3858/emm.2010.42.9.065ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9739-
dc.description.abstractSuccessful hematopoietic stem cell transplantation (HSCT) involves the restoration of hematopoietic function after engraftment, arising from the differentiation and proliferation of hematopoietic stem cells. Several factors could influence the course of allogeneic-HSCT (allo-HSCT). Therefore, knowledge of serum proteome changes during the allo-HSCT period might increase the efficacy of diagnosis and disease prevention efforts. This study conducted proteomic analyses to find proteins that were significantly altered in response to allo-HSCT. Sera from five representative patients who underwent allo-HSCT were analyzed by 2-dimen-sional gel electrophoresis and liquid chromatography tandem mass spectrometry, and were measured on a weekly basis before and after allo-HSCT in additional 78 patients. Fourteen protein spots showing changes in expression were further examined, and most proteins were identified as acute phase proteins (APPs). Studies of 78 additional patients confirmed that C-re-active protein (CRP) and haptoglobin undergo expression changes during allo-HSCT and thus may have the potential to serve as representative markers of clinical events after allo-HSCT. Maximal CRP level affected the development of major transplant-related complications (MTCs) and other problems such as fever of unknown origin. Particularly, an increase in CRP level 21 days after allo-HSCT was found to be an independent risk factor for MTC. Maximal haptoglobin and hapto-globin level 14 days after allo-HSCT were predictive of relapses in underlying hematologic disease. Our results indicated that CRP and haptoglobin were significantly expressed during allo-HSCT, and suggest that their level can be monitored after allo-HSCT to assess the risks of early transplant-related complications and relapse.-
dc.publisherSpringer-Nature Pub Group-
dc.titleChange in serum proteome during allogenic hematopoietic stem cell transplantation and clinical significance of serum C-reactive protein and haptoglobin-
dc.title.alternativeChange in serum proteome during allogenic hematopoietic stem cell transplantation and clinical significance of serum C-reactive protein and haptoglobin-
dc.typeArticle-
dc.citation.titleExperimental and Molecular Medicine-
dc.citation.number9-
dc.citation.endPage661-
dc.citation.startPage651-
dc.citation.volume42-
dc.contributor.affiliatedAuthorJoohyun Ryu-
dc.contributor.affiliatedAuthorSung Goo Park-
dc.contributor.affiliatedAuthorSunghyun Kang-
dc.contributor.affiliatedAuthorByoung Chul Park-
dc.contributor.alternativeName유주현-
dc.contributor.alternativeName이세련-
dc.contributor.alternativeName박성구-
dc.contributor.alternativeName강성현-
dc.contributor.alternativeName김형준-
dc.contributor.alternativeName박병철-
dc.identifier.bibliographicCitationExperimental and Molecular Medicine, vol. 42, no. 9, pp. 651-661-
dc.identifier.doi10.3858/emm.2010.42.9.065-
dc.subject.keywordBiological markers-
dc.subject.keywordC-reactive protein-
dc.subject.keywordHaptoglobin-
dc.subject.keywordHematopoietic stem cell transplantation-
dc.subject.keywordProteomics-
dc.subject.keywordRecurrence-
dc.subject.localbiological marker-
dc.subject.localBiological markers-
dc.subject.localC-reactive protein-
dc.subject.localC-reactive protein (CRP)-
dc.subject.localHaptoglobin-
dc.subject.localHematopoietic stem cell transplantation-
dc.subject.localProteomic-
dc.subject.localProteomics-
dc.subject.localrecurrence-
dc.subject.localRecurrence-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Disease Target Structure Research Center > 1. Journal Articles
Critical Diseases Diagnostics Convergence Research Center > 1. Journal Articles
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