Kansuinine A and Kansuinine B from Euphorbia kansui L. Inhibit IL-6-induced Stat3 Activation = 감수로부터 분리한 칸수이닌 A와 B의 IL-6유도 STAT3활성저해

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Title
Kansuinine A and Kansuinine B from Euphorbia kansui L. Inhibit IL-6-induced Stat3 Activation = 감수로부터 분리한 칸수이닌 A와 B의 IL-6유도 STAT3활성저해
Author(s)
Jong Sun Chang; Seung Woong Lee; Mi-Hye Park; M S Kim; B I Hudson; Su-Jin ParkWoo Song LeeMun Chual Rho
Bibliographic Citation
Planta Medica, vol. 76, no. 14, pp. 1544-1549
Publication Year
2010
Abstract
The current study was performed to examine the mechanisms underlying the potential effects of E. kansui on IL-6-induced cellular signaling in human hepatoma cells. We found that two diterpenoids, kansuinine A and B, from E. kansui have an inhibitory effect on IL-6-induced Stat3 activation by activating ERK1/2. Inhibition of MEK significantly blocked the effects of kansuinine A and B on IL-6-induced Stat3 activation and tyrosine phosphorylation. These results suggest that blocking of IL-6-induced signal transduction is partially due to the sustained activation of ERK1/2 by kansuinine A and B, which in turn results in an increase of Stat3 serine phosphorylation and SOCS-3 expression. Treatment with kansuinine A and B represents a novel method to block these IL-6-induced effects.
Keyword
ERK1/2Euphorbia kansui LiouEuphorbiaceaeIL6kansuinine Akansuinine BStat3
ISSN
0032-0943
Publisher
Georg Thieme Verlag Kg
DOI
http://dx.doi.org/10.1055/s-0030-1249805
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
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