Alu-derived old world monkeys exonization event and experimental validation of the LEPR gene

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dc.contributor.authorJae Won Huh-
dc.contributor.authorYoung-Hyun Kim-
dc.contributor.authorDae Soo Kim-
dc.contributor.authorSang Je Park-
dc.contributor.authorSang Rae Lee-
dc.contributor.authorSang-Hyun Kim-
dc.contributor.authorEkyune Kim-
dc.contributor.authorSun-Uk Kim-
dc.contributor.authorM S Kim-
dc.contributor.authorH S Kim-
dc.contributor.authorKyu Tae Chang-
dc.date.accessioned2017-04-19T09:19:51Z-
dc.date.available2017-04-19T09:19:51Z-
dc.date.issued2010-
dc.identifier.issn1016-8478-
dc.identifier.uri10.1007/s10059-010-0108-xko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9763-
dc.description.abstractThe leptin receptor (LEPR) is a crucial regulatory protein that interacts with Leptin. In our analysis of LEPR, novel AluJb-derived alternative transcripts were identified in the genome of the rhesus monkey. In order to investigate the occurrence of AluJb-derived alternative transcripts and the mechanism underlying exonization events, we conducted analyses using a number of primate genomic DNAs and adipose RNAs of tissue and primary cells derived from the crab-eating monkey. Our results demonstrate that the AluJb element has been integrated into our common ancestor genome prior to the divergence of simians and prosimians. The lineage-specific exonization event of the LEPR gene in chimpanzees, orangutans, and Old World monkeys appear to have been accomplished via transition mutations of the 5′ splicing site (second position of C to T). However, in New World monkeys and prosimians, the AluJb-related LEPR transcript should be silenced by the additional transversion mutation (fourth position of T to G). The AluJb-related transcript of human LEPR should also be silenced by a mutation of the 5′ splicing site (first position of G to A) and the insertion of one nucleotide sequence (minus fourth position of A). Our data suggests that lineage-specific exonization events should be determined by the combination event of the formation of splicing sites and protection against site-specific mutation pressures. These evolutionary mechanisms could be major sources for primate diversification.-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleAlu-derived old world monkeys exonization event and experimental validation of the LEPR gene-
dc.title.alternativeAlu-derived old world monkeys exonization event and experimental validation of the LEPR gene-
dc.typeArticle-
dc.citation.titleMolecules and Cells-
dc.citation.number3-
dc.citation.endPage207-
dc.citation.startPage201-
dc.citation.volume30-
dc.contributor.affiliatedAuthorJae Won Huh-
dc.contributor.affiliatedAuthorYoung-Hyun Kim-
dc.contributor.affiliatedAuthorDae Soo Kim-
dc.contributor.affiliatedAuthorSang Je Park-
dc.contributor.affiliatedAuthorSang Rae Lee-
dc.contributor.affiliatedAuthorSang-Hyun Kim-
dc.contributor.affiliatedAuthorEkyune Kim-
dc.contributor.affiliatedAuthorSun-Uk Kim-
dc.contributor.affiliatedAuthorKyu Tae Chang-
dc.contributor.alternativeName허재원-
dc.contributor.alternativeName김영현-
dc.contributor.alternativeName김대수-
dc.contributor.alternativeName박상제-
dc.contributor.alternativeName이상래-
dc.contributor.alternativeName김상현-
dc.contributor.alternativeName김익균-
dc.contributor.alternativeName김선욱-
dc.contributor.alternativeName김명수-
dc.contributor.alternativeName김희수-
dc.contributor.alternativeName장규태-
dc.identifier.bibliographicCitationMolecules and Cells, vol. 30, no. 3, pp. 201-207-
dc.identifier.doi10.1007/s10059-010-0108-x-
dc.subject.keywordalternative transcript-
dc.subject.keywordAluJb-
dc.subject.keywordexonization event-
dc.subject.keywordleptin receptor-
dc.subject.keywordtransposable elements-
dc.subject.localAlternative transcripts-
dc.subject.localalternative transcript-
dc.subject.localAluJb-
dc.subject.localexonization event-
dc.subject.localleptin receptor-
dc.subject.localtransposable elements-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > National Primate Research Center > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > Futuristic Animal Resource & Research Center > 1. Journal Articles
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