Zinc-finger protein 91 plays a key role in LIGHT-induced activation of non-canonical NF-κB pathway

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Title
Zinc-finger protein 91 plays a key role in LIGHT-induced activation of non-canonical NF-κB pathway
Author(s)
H R Jin; X Jin; Jung Joon Lee
Bibliographic Citation
Biochemical and Biophysical Research Communications, vol. 400, no. 4, pp. 581-586
Publication Year
2010
Abstract
LIGHT is a member of tumor necrosis factor (TNF) superfamily, and its function is mediated through lymphotoxin-β receptor (LTβR), which is known to play important roles in inflammatory and immune responses through activation of NF-κB signaling pathways. However, molecular mechanism of LTβR ligation-induced NF-κB signaling remains incompletely understood. In this report we demonstrate that a novel zinc-finger protein 91 (ZFP91) is a critical regulator in LIGHT-induced activation of non-canonical NF-κB pathway. ZFP91 appears to be required for NF-κB2 (p100) processing to p52, nuclear translocation of p52 and RelB, and DNA-binding activity of NF-κB in LIGHT-induced activation of non-canonical NF-κB pathway. Furthermore, ZFP91 knock-down by RNA interference blocks the LIGHT-induced accumulation of NIK and p100 processing, as well as the expression of non-canonical NF-κB target genes. These data clearly indicate that ZFP91 is a key regulator in LIGHT-induced activation of non-canonical NF-κB pathway in LTβR signaling.
Keyword
LIGHTLTβRNF-κBNIKP52ZFP91
ISSN
0006-291X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bbrc.2010.08.107
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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