An isoaurone and other constituents from Trichosanthes kirilowii seeds inhibit hypoxia-inducible factor-1 and nuclear factor-kappaB

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dc.contributor.authorN T Dat-
dc.contributor.authorX Jin-
dc.contributor.authorYoung-Soo Hong-
dc.contributor.authorJung Joon Lee-
dc.date.accessioned2017-04-19T09:19:52Z-
dc.date.available2017-04-19T09:19:52Z-
dc.date.issued2010-
dc.identifier.issn01633864-
dc.identifier.uri10.1021/np900820pko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9772-
dc.description.abstractHypoxia-inducible factor-1 and nuclear factor-κB have become important targets in cancer treatment due to their critical role in the regulation of genes involved in tumorigenesis. Bioassay-guided fractionation of the methanol extract of Trichosanthes kirilowii seeds led to the isolation of a naturally rare isoaurone, 4′,6-dihydroxy-4-methoxyisoaurone (1), together with three known compounds, cucurbitacin B (2), 6-(3-hydroxy-4-methoxystyryl)-4- methoxy-2H-pyran-2-one (3), and blumenol A (4). All compounds inhibited HIF-1 and NF-κB activities in reporter assays. Compounds 1-3 potently inhibited HIF-1α accumulation and VEGF secretion under hypoxic condition. These results suggest that the tumor cell growth inhibitory activity of T. kirilowii is likely associated with the inhibition of HIF-1 and NF-κB activities.-
dc.publisherAmer Chem Soc-
dc.titleAn isoaurone and other constituents from Trichosanthes kirilowii seeds inhibit hypoxia-inducible factor-1 and nuclear factor-kappaB-
dc.title.alternativeAn isoaurone and other constituents from Trichosanthes kirilowii seeds inhibit hypoxia-inducible factor-1 and nuclear factor-kappaB-
dc.typeArticle-
dc.citation.titleJournal of Natural Products-
dc.citation.number6-
dc.citation.endPage1169-
dc.citation.startPage1167-
dc.citation.volume73-
dc.contributor.affiliatedAuthorYoung-Soo Hong-
dc.contributor.alternativeNameDat-
dc.contributor.alternativeNameJin-
dc.contributor.alternativeName홍영수-
dc.contributor.alternativeName이정준-
dc.identifier.bibliographicCitationJournal of Natural Products, vol. 73, no. 6, pp. 1167-1169-
dc.identifier.doi10.1021/np900820p-
dc.description.journalClassY-
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Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
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