In vitro anti-rotavirus activity of polyphenol compounds isolated from the roots of Glycyrrhiza uralensis = 감초로부터 항로타바이러스활성을 지니는 폴리페놀화합물의 개발

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dc.contributor.authorHyung Jun Kwon-
dc.contributor.authorHa-Hyeon Kim-
dc.contributor.authorYoung Bae Ryu-
dc.contributor.authorJang Hoon Kim-
dc.contributor.authorHyung Jae Jung-
dc.contributor.authorSeung Woong Lee-
dc.contributor.authorJong Sun Chang-
dc.contributor.authorK O Cho-
dc.contributor.authorMun Chual Rho-
dc.contributor.authorSu-Jin Park-
dc.contributor.authorWoo Song Lee-
dc.date.accessioned2017-04-19T09:19:52Z-
dc.date.available2017-04-19T09:19:52Z-
dc.date.issued2010-
dc.identifier.issn09680896-
dc.identifier.uri10.1016/j.bmc.2010.07.073ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9773-
dc.description.abstractWe evaluated the ability of six polyphenols isolated from the roots of Glycyrrhiza uralensis to inactivate rotaviruses, specially G5P[7] and G8P[7]. Upon finding that all polyphenols possessed anti-rotavirus activity, we evaluated whether these properties were attributable to direct inhibition of the binding of rotavirus to cells and/or to inhibition of viral replication. Using the virucidal assay, we found that all six compounds directly inhibited rotavirus binding, with activity being dependent on the type of virus. The 50% effective inhibitory concentrations (EC50) of the six compounds were 18.7-69.5 μM against G5P[7] and 14.7-88.1 μM against G8P[7], respectively. Five of the six compounds inhibited hemagglutination activity. Moreover, the CPE inhibition assay showed that five compounds inhibited viral replication with EC50 values of 12.1-24.0 μM against G5P[7] and 12.0-42.0 μM against G8P[7], respectively. RT-PCR showed that the compounds suppressed viral RNA synthesis in TF-104 cells. Interestingly, the anti-rotavirus activities of four compounds were attributable to inhibition of both viral absorption and viral replication. These results suggest that compounds isolated from the roots of G. uralensis may be potent anti-rotavirus agents in vivo, acting by inhibiting both viral absorption and viral replication.-
dc.publisherElsevier-
dc.titleIn vitro anti-rotavirus activity of polyphenol compounds isolated from the roots of Glycyrrhiza uralensis = 감초로부터 항로타바이러스활성을 지니는 폴리페놀화합물의 개발-
dc.title.alternativeIn vitro anti-rotavirus activity of polyphenol compounds isolated from the roots of Glycyrrhiza uralensis-
dc.typeArticle-
dc.citation.titleBioorganic & Medicinal Chemistry-
dc.citation.number21-
dc.citation.endPage7674-
dc.citation.startPage7668-
dc.citation.volume18-
dc.contributor.affiliatedAuthorHyung Jun Kwon-
dc.contributor.affiliatedAuthorYoung Bae Ryu-
dc.contributor.affiliatedAuthorHyung Jae Jung-
dc.contributor.affiliatedAuthorSeung Woong Lee-
dc.contributor.affiliatedAuthorMun Chual Rho-
dc.contributor.affiliatedAuthorSu-Jin Park-
dc.contributor.affiliatedAuthorWoo Song Lee-
dc.contributor.alternativeName권형준-
dc.contributor.alternativeName김하현-
dc.contributor.alternativeName류영배-
dc.contributor.alternativeName김장훈-
dc.contributor.alternativeName정형재-
dc.contributor.alternativeName이승웅-
dc.contributor.alternativeName장종선-
dc.contributor.alternativeName조경오-
dc.contributor.alternativeName노문철-
dc.contributor.alternativeName박수진-
dc.contributor.alternativeName이우송-
dc.identifier.bibliographicCitationBioorganic & Medicinal Chemistry, vol. 18, no. 21, pp. 7668-7674-
dc.identifier.doi10.1016/j.bmc.2010.07.073-
dc.subject.keywordAnti-rotavirus-
dc.subject.keywordGlycyrrhiza uralensis-
dc.subject.keywordHemagglutinin-
dc.subject.keywordViral absorption-
dc.subject.keywordViral replication-
dc.subject.localAnti-rotavirus-
dc.subject.localGlycyrrhiza uralensis-
dc.subject.localHemagglutinin-
dc.subject.localViral absorption-
dc.subject.localViral replication-
dc.description.journalClassY-
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
Jeonbuk Branch Institute > Immunoregulatory materials Research Center > 1. Journal Articles
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