Synthesis and antifungal activity of a novel series of 13-(4-isopropylbenzyl)berberine derivatives = 새로운 13-(4-아이소프로필벤질)버버린 유도체의 합성과 항진균 활성

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dc.contributor.authorK D Park-
dc.contributor.authorS J Cho-
dc.contributor.authorJae Sun Moon-
dc.contributor.authorSung Uk Kim-
dc.date.accessioned2017-04-19T09:19:53Z-
dc.date.available2017-04-19T09:19:53Z-
dc.date.issued2010-
dc.identifier.issn0960-894X-
dc.identifier.uri10.1016/j.bmcl.2010.09.045ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9774-
dc.description.abstractBy replacing the methyl group of 13-(4-isopropylbenzyl)berberine 2 with various acyl, alkyl, and benzyl groups via the demethylated intermediate, 13-(4-isopropylbenzyl)berberrubine 4, a novel series of 9-O-alkyl-13-(4- isopropylbenzyl)berberine derivatives was synthesized and examined for antifungal activities against various human pathogenic fungi. The introduction of various alkyl groups led to enhanced antifungal activity but that of acyl groups resulted in decrease of the activity. Among them, 9-O-butyl-13-(4- isopropylbenzyl)berberine 6d exhibited the most potent antifungal activities against Cryptococcus neoformans, Candida species (MIC = 0.25-1 μg/ml), and Aspergillus species (MIC = 2-4 μg/ml). The compound was found to be relatively safe up to 900 mg/kg in oral administration to mice.-
dc.publisherElsevier-
dc.titleSynthesis and antifungal activity of a novel series of 13-(4-isopropylbenzyl)berberine derivatives = 새로운 13-(4-아이소프로필벤질)버버린 유도체의 합성과 항진균 활성-
dc.title.alternativeSynthesis and antifungal activity of a novel series of 13-(4-isopropylbenzyl)berberine derivatives-
dc.typeArticle-
dc.citation.titleBioorganic & Medicinal Chemistry Letters-
dc.citation.number22-
dc.citation.endPage6554-
dc.citation.startPage6551-
dc.citation.volume20-
dc.contributor.affiliatedAuthorJae Sun Moon-
dc.contributor.affiliatedAuthorSung Uk Kim-
dc.contributor.alternativeName박기덕-
dc.contributor.alternativeName조성진-
dc.contributor.alternativeName문제선-
dc.contributor.alternativeName김성욱-
dc.identifier.bibliographicCitationBioorganic & Medicinal Chemistry Letters, vol. 20, no. 22, pp. 6551-6554-
dc.identifier.doi10.1016/j.bmcl.2010.09.045-
dc.subject.keyword13-(4-Isopropylbenzyl)berberine-
dc.subject.keywordAntifungal activity-
dc.subject.keywordBerberine derivatives-
dc.subject.keywordHuman pathogenic fungi-
dc.subject.local13-(4-Isopropylbenzyl)berberine-
dc.subject.localAntifungal activity-
dc.subject.localAnti-fungal activity-
dc.subject.localantifungal activity-
dc.subject.localBerberine derivatives-
dc.subject.localHuman pathogenic fungi-
dc.description.journalClassY-
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Division of Research on National Challenges > Plant Systems Engineering Research > 1. Journal Articles
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