Human acyl-CoA:cholesterol acyltransferase-inhibiting dammarane triperpenes from Rhus chinensis

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Title
Human acyl-CoA:cholesterol acyltransferase-inhibiting dammarane triperpenes from Rhus chinensis
Author(s)
G S Kim; Tae Sook Jeong; Y O Kim; N I Baek; S W Cha; J W Lee; K S Song
Bibliographic Citation
Journal of Korean Society for Applied Biological Chemistry, vol. 53, no. 4, pp. 417-421
Publication Year
2010
Abstract
In the process of screening for anti-human acyl-CoA:cholesterol acyltransferase (hACAT) agents from plant resources, we found that the 80% methanolic extract of Rhus chinensis (R. chinensis) exhibited significant antioxidative and hACAT activities in rats. Two compounds were isolated as active principles from the ethyl acetate soluble fraction of the branches of R. chinensis. The structures of compounds 1 and 2 were determined as hydroxydammarenone and semialactone, respectively, by means of MS and NMR spectroscopic analysis. Compound 1 has been isolated from this plant for the first time. Compounds 1 and 2 showed inhibitory activities on both human ACAT1 with IC50 values of 12.4, and 79.1 μM and on human ACAT2 with IC50 values of 30.5 and 76.9 μM, respectively. These results suggested that R. chinensis containing dammarane triterpenes 1 and 2 might be effective in the prevention and treatment of hypercholesterolemia or atherosclerosis via inhibitory effect on hACAT.
Keyword
atherosclerosishACAThydroxydammarenonehypercholesterolemiaRhus chinensissemialactone
ISSN
I000-0171
Publisher
Korea Soc-Assoc-Inst
DOI
http://dx.doi.org/10.3839/jksabc.2010.064
Type
Article
Appears in Collections:
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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