Expression of hepatitis B virus X protein in hepatocytes suppresses CD8+ T cell activity

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Title
Expression of hepatitis B virus X protein in hepatocytes suppresses CD8+ T cell activity
Author(s)
M J Lee; Y H Jin; K Kim; Y Choi; Hyoung-Chin Kim; S Park
Bibliographic Citation
Immune Network, vol. 10, no. 4, pp. 126-134
Publication Year
2010
Abstract
BACKGROUND: CD8(+) T cells contribute to the clearance of Hepatitis B virus (HBV) infection and an insufficient CD8(+) T cell response may be one of the major factors leading to chronic HBV infection. Since the HBx antigen of HBV can up-regulate cellular expression of several immunomodulatory molecules, we hypothesized that HBx expression in hepatocytes might affect CD8(+) T cell activity. METHODS: We analyzed the activation and apoptosis of CD8(+) T cells co-cultured with primary hepatocytes rendered capable of expressing HBx by recombinant baculovirus infection. RESULTS: Expression of HBx in hepatocytes induced low production of interferon-γ and apoptosis of CD8(+) T cells, with no effect on CD8 T cell proliferation. However, transcriptional levels of H-2K, ICAM-1 and PD-1 ligand did not correlate with HBx expression in hepatocytes. CONCLUSION: Our results suggest that HBx may inhibit CD8(+) T cell response by regulation of interferon-γ production and apoptosis.
Keyword
HepadnaviridaeT-lymphocytesCytotoxicViral proteinsApoptosisInterferon-γ
ISSN
I000-0135
Publisher
Korea Soc-Assoc-Inst
DOI
http://dx.doi.org/10.4110/in.2010.10.4.126
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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