Design, synthesis, and anticancer activities of novel perfluoroalkyltriazole-appended 2'-deoxyuridines

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Title
Design, synthesis, and anticancer activities of novel perfluoroalkyltriazole-appended 2'-deoxyuridines
Author(s)
S M Park; H Yang; Song Kyu Park; Hwan Mook Kim; B H Kim
Bibliographic Citation
Bioorganic & Medicinal Chemistry Letters, vol. 20, no. 19, pp. 5831-5834
Publication Year
2010
Abstract
We have focused on the C5-modification of 2′-deoxyuridine with substituted heterocycles for bioactivity, such as antiviral or anticancer activity. Herein, we report a novel class of nucleoside analogues with perfluoroalkyltriazole moiety as an anticancer drug candidate.
Keyword
1,3-Dipolar cycloaddition reaction2′-DeoxyuridineAnticancer activityPerfluoroalkyltriazole
ISSN
0960-894X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bmcl.2010.07.126
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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