Eudesmols induce apoptosis through release of cytochrome c in HL-60 cells

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Title
Eudesmols induce apoptosis through release of cytochrome c in HL-60 cells
Author(s)
D M Hoang; T N Trung; L He; D T Ha; M Lee; Bo Yeon Kim; H V Luong; Jong Seog Ahn; K Bae
Bibliographic Citation
Natural Products Sciences, vol. 16, no. 2, pp. 88-92
Publication Year
2010
Abstract
We verified that the apoptosis activities were examined by DNA fragmentation, flow cytometric analysis with annexin V staining, activation of caspase-3, and cytochrome c release. In the result, α- and β-eudesmol induced DNA fragmentation in HL-60 cells at a concentration of 80 μM, respectively. Additionally, pro-apoptotic cells sorted by flow cytometry analysis were detected in HL-60 cells to 31.77 and 29.67% with a-and β-eudesmol of 80 μM. Thus, both α- and β-eudesmol exerted caspase-3 activation and cytochrome c release at 80 μM in HL-60 cells. These results are firstly reported that the sesquiterpenes, α- and β-eudesmol are apoptosis inducers through mitochondria-dependent caspase cascade in HL-60 cells.
Keyword
Magnolia obovatasesquiterpeneeudesmolsapoptosis inducerphytochemical
ISSN
I000-0147
Publisher
Korean Society of Pharmacognosy
Type
Article
Appears in Collections:
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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