Mechanism of anguillosporal inhibitory activity for phospholipase C as the signal transducer in the biological networking = 생체내 정보 전달계 효소인 phospholipase C 활성을 저해하는 anguillosporal의 작용기전

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dc.contributor.authorJ W Lee-
dc.contributor.authorBo Yeon Kim-
dc.contributor.authorJong Seog Ahn-
dc.date.accessioned2017-04-19T09:20:00Z-
dc.date.available2017-04-19T09:20:00Z-
dc.date.issued2010-
dc.identifier.issnI000-0190-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9805-
dc.description.abstractAnguillosporal dose-dependently inhibited phospholipase C (PLC)γ1 activity in A431 cells in response to epidermal growth factor (EGF). The compound also inhibited PLCβ1 activity in α-thrombin- stimulated CCL39 cells. In accordance with this, PLCγ1 and PLCβ1 activities were also decreased by anguillosporal in vitro. However, anguillosporal did not reduce the auto- phosphorylation of EGFR and the tyrosine phosphorylation of PLCγ1 in EGF-stimulated A431 cells. Also anguillosporal did not inhibit the tyrosine kinase activity of EGFR. From these results, it is suggested that anguillosporal is a specific inhibitor of phospholipase C.-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleMechanism of anguillosporal inhibitory activity for phospholipase C as the signal transducer in the biological networking = 생체내 정보 전달계 효소인 phospholipase C 활성을 저해하는 anguillosporal의 작용기전-
dc.title.alternativeMechanism of anguillosporal inhibitory activity for phospholipase C as the signal transducer in the biological networking-
dc.typeArticle-
dc.citation.title한국지식정보기술학회 논문지-
dc.citation.number4-
dc.citation.endPage26-
dc.citation.startPage19-
dc.citation.volume5-
dc.contributor.affiliatedAuthorBo Yeon Kim-
dc.contributor.affiliatedAuthorJong Seog Ahn-
dc.contributor.alternativeName이준원-
dc.contributor.alternativeName김보연-
dc.contributor.alternativeName안종석-
dc.identifier.bibliographicCitation한국지식정보기술학회 논문지, vol. 5, no. 4, pp. 19-26-
dc.subject.keywordAnguillosporal-
dc.subject.keywordphospholipase C-
dc.subject.keywordtyrosine phosphorylation-
dc.subject.keywordtyrosine kinase e-
dc.subject.localAnguillosporal-
dc.subject.localanguillosporal-
dc.subject.localphospholipase C-
dc.subject.localPhospholipase C-
dc.subject.localTyrosine phosphorylation-
dc.subject.localTyrosine Phosphorylation-
dc.subject.localtyrosine phosphorylation-
dc.subject.localtyrosine kinase e-
dc.description.journalClassN-
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Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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