DC Field | Value | Language |
---|---|---|
dc.contributor.author | J W Lee | - |
dc.contributor.author | Bo Yeon Kim | - |
dc.contributor.author | Jong Seog Ahn | - |
dc.date.accessioned | 2017-04-19T09:20:00Z | - |
dc.date.available | 2017-04-19T09:20:00Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | I000-0190 | - |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/9805 | - |
dc.description.abstract | Anguillosporal dose-dependently inhibited phospholipase C (PLC)γ1 activity in A431 cells in response to epidermal growth factor (EGF). The compound also inhibited PLCβ1 activity in α-thrombin- stimulated CCL39 cells. In accordance with this, PLCγ1 and PLCβ1 activities were also decreased by anguillosporal in vitro. However, anguillosporal did not reduce the auto- phosphorylation of EGFR and the tyrosine phosphorylation of PLCγ1 in EGF-stimulated A431 cells. Also anguillosporal did not inhibit the tyrosine kinase activity of EGFR. From these results, it is suggested that anguillosporal is a specific inhibitor of phospholipase C. | - |
dc.publisher | Korea Soc-Assoc-Inst | - |
dc.title | Mechanism of anguillosporal inhibitory activity for phospholipase C as the signal transducer in the biological networking = 생체내 정보 전달계 효소인 phospholipase C 활성을 저해하는 anguillosporal의 작용기전 | - |
dc.title.alternative | Mechanism of anguillosporal inhibitory activity for phospholipase C as the signal transducer in the biological networking | - |
dc.type | Article | - |
dc.citation.title | 한국지식정보기술학회 논문지 | - |
dc.citation.number | 4 | - |
dc.citation.endPage | 26 | - |
dc.citation.startPage | 19 | - |
dc.citation.volume | 5 | - |
dc.contributor.affiliatedAuthor | Bo Yeon Kim | - |
dc.contributor.affiliatedAuthor | Jong Seog Ahn | - |
dc.contributor.alternativeName | 이준원 | - |
dc.contributor.alternativeName | 김보연 | - |
dc.contributor.alternativeName | 안종석 | - |
dc.identifier.bibliographicCitation | 한국지식정보기술학회 논문지, vol. 5, no. 4, pp. 19-26 | - |
dc.subject.keyword | Anguillosporal | - |
dc.subject.keyword | phospholipase C | - |
dc.subject.keyword | tyrosine phosphorylation | - |
dc.subject.keyword | tyrosine kinase e | - |
dc.subject.local | Anguillosporal | - |
dc.subject.local | anguillosporal | - |
dc.subject.local | phospholipase C | - |
dc.subject.local | Phospholipase C | - |
dc.subject.local | Tyrosine phosphorylation | - |
dc.subject.local | Tyrosine Phosphorylation | - |
dc.subject.local | tyrosine phosphorylation | - |
dc.subject.local | tyrosine kinase e | - |
dc.description.journalClass | N | - |
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