Fabrication of a structure-specific RNA binder for array detection of label-free microRNA = 신규 RNA 결합단백질의 개발을 통한 마이크로 RNA 어레이 분석

Abstract

Like an antibody: A novel structure-specific RNA-binding protein was designed to stably and specifically bind to surface-bound microRNAs. By acting like an antibody, this RNA binder enabled the universal detection of hybridized microRNAs on array surfaces (see picture) without any enzymatic amplification or labeling reactions. ⓒ 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.