Fabrication of a structure-specific RNA binder for array detection of label-free microRNA = 신규 RNA 결합단백질의 개발을 통한 마이크로 RNA 어레이 분석

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Title
Fabrication of a structure-specific RNA binder for array detection of label-free microRNA = 신규 RNA 결합단백질의 개발을 통한 마이크로 RNA 어레이 분석
Author(s)
Jeong Min Lee; Hyeon Min Jo; Yongwon Jung
Bibliographic Citation
Angewandte Chemie-International Edition, vol. 49, no. 46, pp. 8662-8665
Publication Year
2010
Abstract
Like an antibody: A novel structure-specific RNA-binding protein was designed to stably and specifically bind to surface-bound microRNAs. By acting like an antibody, this RNA binder enabled the universal detection of hybridized microRNAs on array surfaces (see picture) without any enzymatic amplification or labeling reactions. ⓒ 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Keyword
biosensorsmicroarraysmicroRNAprotein designRNA recognition
ISSN
1433-7851
Publisher
Wiley
DOI
http://dx.doi.org/10.1002/anie.201004000
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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